Table 1 Clinical features at the diagnosis of primary hypothyroidism
From: Growth impairment in children with atrophic autoimmune thyroiditis and pituitary hyperplasia
Patients | Sex | Age (years) | Height, cm (SDS) | Target Height SDS | BMI, Kg/m2 (SDS) | Bone Age | Pubertal Tanner’s Stage (B/G-P) | Main symptoms and clinical findings |
|---|---|---|---|---|---|---|---|---|
Patient 1 | F | 13 | 132.8 (-3.58) | -0.59 | 22.4 (1.08) | 10.25 | B2P1 | GA, dry and thickened skin |
Patient 2 | F | 11 | 130 (-2.3) | NA | 20.41 (1.16) | 11.3 | B1P2 | GA, hypokinetic, apathy, constipation |
Patient 3 | F | 8 | 123.9 (-0.84) | -0.81 | 18.11 (1.06) | 6.2 | B1P1 | GA, dry and thickened skin |
Patient 4 | M | 11.7 | 135.2 (-1.67) | -0.9 | 23.5 (2.08) | 8.6 | G1P1 | GA, hypokinetic, apathy, fatigue, constipation, sleepiness, impaired school performance, cold intolerance, bradycardia, sparse brittle hair, dry and thickened skin |
Patient 5 | M | 14.8 | 151.3 (-2.09) | 0.7 | 21.57 (0.71) | 12.6 | G2P2 | GA, hypokinetic, apathy, fatigue, constipation, sleepiness, cold intolerance, bradycardia, sparse brittle hair, dry and thickened skin |
Patient 6 | F | 8.5 | 113.3 (-2.7) | -0.6 | 17.7 (0.87) | 3.6 | B1P1 | GA, hypokinetic, apathy, fatigue, constipation, sleepiness, cold intolerance, bradycardia, dry and thickened skin |
Patient 7 | F | 8.5 | 119 (-1.74) | -0.6 | 15.9 (0.01) | 5.6 | B1P1 | GA, hypokinetic, apathy, fatigue, constipation, sleepiness, cold intolerance, bradycardia, dry and thickened skin |
Patient 8 | M | 11.1 | 129 (-2.19) | NA | 21.6 (1.74) | 6 | G1P1 | PG, hypokinetic, apathy, impaired school performance, bradycardia, sparse brittle hair, dry and thickened skin |
Patient 9 | F | 8.1 | 123 (-0.75) | NA | 21.5 (2.22) | 8.1 | B2P1 | PG, hypokinetic, fatigue, cold intolerance, dry and thickened skin |
Patient 10 | M | 11.5 | 151.5 (0.78) | 0.4 | 29.8 (3.13) | 11.5 | G1P2 | PG, hypokinetic, apathy, fatigue, impaired school performance |
Patient 11 | M | 14.62 | 158.8 (-1.05) | NA | 20 (0.22) | 14 | G5P4 | GA, dry and thickened skin, hypokinetic, fatigue, sleepiness, cold intolerance |
Patient 12 | M | 12.39 | 133 (-2.59) | NA | 26.6 (2.46) | 6.5 | G4P2 | GA, bradycardia, sparse brittle hair, dry and thickened skin, hypokinetic, fatigue, constipation, sleepiness, impaired school performance, cold intolerance |