Allergology and Immunology

This section considers studies regarding the epidemiology, pathology, prevention, and control of allergic and immunologic diseases in children and adolescents.

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  1. Research

    Resveratrol plus carboxymethyl-β-glucan in children with recurrent respiratory infections: a preliminary and real-life experience

    Recurrent respiratory infections (RRI), such as the presence of at least one of the following criteria: i) >6 RI per year; ii) >1 RI per month involving upper airways from September to April; iii) >3 RI involv...

    Alfonso Maria Varricchio, Michele Capasso, Antonio della Volpe, Luigi Malafronte, Nicola Mansi, Attilio Varricchio and Giorgio Ciprandi

    Italian Journal of Pediatrics 2014 40:93

    Published on: 23 November 2014

  2. Case report

    Severe congenital neutropenia due to G6PC3 deficiency: early and delayed phenotype in two patients with two novel mutations

    Severe Congenital Neutropenia type 4 (SCN4, OMIM 612541) is a rare autosomal recessive disease due to mutations in the G6PC3 gene. The phenotype comprises neutropenia of variable severity and other anomalies incl...

    Lucia Dora Notarangelo, Gianfranco Savoldi, Sara Cavagnini, Veronica Bennato, Sabrina Vasile, Alba Pilotta, Alessandro Plebani and Fulvio Porta

    Italian Journal of Pediatrics 2014 40:80

    Published on: 14 November 2014

  3. Case report

    Late-onset of immunodysregulation, polyendocrinopathy, enteropathy, x-linked syndrome (IPEX) with intractable diarrhea

    The syndrome of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) is a rare disorder caused by mutations in the FOXP3 gene. Diarrhea, diabetes and dermatitis are the hallmark of the diseas...

    Daniele Zama, Ilaria Cocchi, Riccardo Masetti, Fernando Specchia, Patrizia Alvisi, Eleonora Gambineri, Mario Lima and Andrea Pession

    Italian Journal of Pediatrics 2014 40:68

    Published on: 18 October 2014

  4. Research

    Atopic dermatitis phenotypes in childhood

    Atopic dermatitis (AD) is a chronic inflammatory skin disease and can be the first step of the atopic march.

    Giampaolo Ricci, Arianna Dondi, Iria Neri, Lorenza Ricci, Annalisa Patrizi and Andrea Pession

    Italian Journal of Pediatrics 2014 40:46

    Published on: 12 May 2014

  5. Research

    Vaccine risk assessment in children with a referred reaction to a previous vaccine dose: 2009–2011 retrospective report at the Bambino Gesu’ children hospital, Rome, Italy

    During the last century, mass vaccination programs have achieved considerable success across the world in immunizing against several serious infectious diseases. However, vaccinations are threatened by their o...

    Luciana Nicolosi, Annachiara Vittucci, Rossella Mancini, Elena Bozzola, Alberto Cagigi, Annalisa Grandin and Alberto Villani

    Italian Journal of Pediatrics 2014 40:31

    Published on: 31 March 2014

  6. Research

    Prevalence and socio-demographic factors associated with non-protective immunity against tetanus among high school adolescents girls in Nigeria

    The low uptake of tetanus vaccine and its resultant high burden of tetanus in Nigeria suggest the need to improve routine and booster vaccination in children and adolescents. However, epidemiological evidence ...

    Adebola E Orimadegun, Akinlolu A Adepoju and Olusegun O Akinyinka

    Italian Journal of Pediatrics 2014 40:29

    Published on: 17 March 2014

  7. Research

    Glutathione S transferase theta1 and mu1 gene polymorphisms and phenotypic expression of asthma in Egyptian children: a case–control study

    Asthma is the result of a complex interaction between environmental factors and genetic variants that confer susceptibility. The glutathione S-transferases (GSTT1 and GSTM1) are phase II enzymes thought to pro...

    Nihal El Rifai, Nadia Moustafa, Nelly Degheidy and Manal Wilson

    Italian Journal of Pediatrics 2014 40:22

    Published on: 21 February 2014

  8. Case report

    Refractory invasive aspergillosis controlled with posaconazole and pulmonary surgery in a patient with chronic granulomatous disease: case report

    Invasive aspergillosis is an important cause of morbidity and mortality in immunocompromised patients. Among primary immunodefiencies, chronic granulomatous disease (CGD) has the highest prevalence of invasive...

    Eda Kepenekli, Ahmet Soysal, Canan Kuzdan, Nezih Onur Ermerak, Mustafa Yüksel and Mustafa Bakır

    Italian Journal of Pediatrics 2014 40:2

    Published on: 8 January 2014

  9. Review

    Nutritional management and follow up of infants and children with food allergy: Italian Society of Pediatric Nutrition/Italian Society of Pediatric Allergy and Immunology Task Force Position Statement

    Although the guidelines on the diagnosis and treatment of food allergy recognize the role of nutrition, there is few literature on the practical issues concerning the nutritional management of children with fo...

    Marcello Giovannini, Enza D'Auria, Carlo Caffarelli, Elvira Verduci, Salvatore Barberi, Luciana Indinnimeo, Iride Dello Iacono, Alberto Martelli, Enrica Riva and Roberto Bernardini

    Italian Journal of Pediatrics 2014 40:1

    Published on: 3 January 2014

  10. Research

    Childhood asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them?

    Epidemiological studies show that vitamin D deficiency and insufficiency are common worldwide and associated with many diseases including asthma. Our aim was to evaluate vitamin D insufficiency and its clinica...

    Metin Uysalol, Levent Cem Mutlu, Gamze Varol Saracoglu, Erkut Karasu, Savas Guzel, Semra Kayaoglu and Nedret Uzel

    Italian Journal of Pediatrics 2013 39:78

    Published on: 13 December 2013

  11. Commentary

    Pidotimod: the past and the present

    At the end of 1990s, acute respiratory tract infections (ARTIs) were called the 'forgotten pandemic’, with a clear dichotomy between developing and industrialised countries in mortality and morbidity, the main...

    Gian Vincenzo Zuccotti and Chiara Mameli

    Italian Journal of Pediatrics 2013 39:75

    Published on: 6 December 2013

  12. Case report

    Nijmegen breakage syndrome and chronic polyarthritis

    We report on pediatric patient with Nijmegen breakage syndrome (NBS), a rare DNA repair disorder characterized by microcephaly, immunodeficiency and predisposition to malignant lymphomas, who developed juvenil...

    Srdjan Pasic, Maja Cupic, Tanja Jovanovic, Slobodanka Djukic, Maja Kavaric and Ivana Lazarevic

    Italian Journal of Pediatrics 2013 39:59

    Published on: 17 September 2013

  13. Case report

    A family history of serious complications due to BCG vaccination is a tool for the early diagnosis of severe primary immunodeficiency

    Severe Combined Immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency (PID). Complications of BCG vaccination, especially disseminated infection and its most severe forms, are kno...

    Pérsio Roxo-Junior, Jorgete Silva, Mauro Andrea, Larissa Oliveira, Fernando Ramalho, Thiago Bezerra and Altacílio A Nunes

    Italian Journal of Pediatrics 2013 39:54

    Published on: 10 September 2013

  14. Review

    Skin prick test to foods in childhood atopic eczema: pros and cons

    Skin prick tests are the first investigation in allergy diagnostics and their use is described in all the guidelines on atopic eczema. However, the clinical usefulness of skin prick tests is the subject of gre...

    Carlo Caffarelli, Arianna Dondi, Carlotta Povesi Dascola and Giampaolo Ricci

    Italian Journal of Pediatrics 2013 39:48

    Published on: 31 July 2013

  15. Review

    Probiotics and food allergy

    The exact prevalence of food allergy in the general population is unknown, but almost 12% of pediatric population refers a suspicion of food allergy. IgE mediated reactions to food are actually the best-charac...

    Anna Maria Castellazzi, Chiara Valsecchi, Silvia Caimmi, Amelia Licari, Alessia Marseglia, Maria Chiara Leoni, Davide Caimmi, Michele Miraglia del Giudice, Salvatore Leonardi, Mario La Rosa and Gian Luigi Marseglia

    Italian Journal of Pediatrics 2013 39:47

    Published on: 29 July 2013

  16. Case report

    Food protein induced enterocolitis syndrome caused by rice beverage

    Food protein-induced enterocolitis syndrome (FPIES) is an uncommon and potentially severe non IgE-mediated gastrointestinal food allergy. It is usually caused by cow’s milk or soy proteins, but may also be tri...

    Lucia Caminiti, Giuseppina Salzano, Giuseppe Crisafulli, Federica Porcaro and Giovanni Battista Pajno

    Italian Journal of Pediatrics 2013 39:31

    Published on: 14 May 2013

  17. Research

    Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression

    Recurrent respiratory infections are one of the most important causes of morbidity in childhood. When immune functions are still largely immature, the airway epithelium plays a primary defensive role since, be...

    Sonia Carta, Michela Silvestri and Giovanni A Rossi

    Italian Journal of Pediatrics 2013 39:29

    Published on: 10 May 2013

  18. Review

    Allergic conjunctivitis: a comprehensive review of the literature

    Ocular allergy represents one of the most common conditions encountered by allergists and ophthalmologists. Allergic conjunctivitis is often underdiagnosed and consequently undertreated. Basic and clinical res...

    Mario La Rosa, Elena Lionetti, Michele Reibaldi, Andrea Russo, Antonio Longo, Salvatore Leonardi, Stefania Tomarchio, Teresio Avitabile and Alfredo Reibaldi

    Italian Journal of Pediatrics 2013 39:18

    Published on: 14 March 2013

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