Table 2 Therapeutic options in gastro-oesophageal reflux in neonates, infants and children according with the strategy steps and the grade of recommendation

Positioning

1

GRADE B (the left lateral position)

Feed frequency

1

GRADE D

Thickened formula or feed

2

GRADE B (for reducing vomiting)

Domperidone

3

GRADE C/D

Ranitidine/cimetidine + PPI

3

GRADE B/C (in relieving esophagitis)

Surgery

4

Surgical intervention is rarely necessary in case of severe complications