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Table 2 Therapeutic options in gastro-oesophageal reflux in neonates, infants and children according with the strategy steps and the grade of recommendation

From: Regurgitation in healthy and non healthy infants

Therapeutic option Strategy Step Grade of recommendation
Positioning 1 GRADE B (the left lateral position)
Feed frequency 1 GRADE D
Thickened formula or feed 2 GRADE B (for reducing vomiting)
Domperidone 3 GRADE C/D
Ranitidine/cimetidine + PPI 3 GRADE B/C (in relieving esophagitis)
Surgery 4 Surgical intervention is rarely necessary in case of severe complications