Table 5 Serum levels of VEGF, PD-ECGF/TP activity and leptin in patients groups in relation to PH, severity of PS, presence or absence of heart failure and cardiomegaly
From: Angiogenic biomarkers in children with congenital heart disease: possible implications
Biomarkers | VEGF (pg/ml) | PD-ECGF (U/ml) | Leptin (ng/ml) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Studied parameters | Â | Cyanotic (n = 30) | Acyanotic (n = 30) | Cyanotic (n = 30) | Acyanotic (n = 30) | Cyanotic (n = 30) | Acyanotic (n = 30) | |||
|  | With (n = 12) | 589 ± 89 | 395 ± 78 | 39.6 ± 4.4 | 30 ± 6.0 | 59.5 ± 6.0 | 44.6 ± 6.1 | |||
PH (n = 12/60) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
|  | Without (n = 48) | 276 ± 92* | 187 ± 85* | 22.2 ± 7.3†| 19.9 ± 5.7†| 30.2 ± 11†| 23.8 ± 5.1†| |||
|  | Severe (n = 21) | 478 ± 74 | 384 ± 62 | 47.3 ± 6.6 | 33 ± 8.9 | 53.6 ± 8.4 | 41 ± 6.5 | |||
PS (n = 24/60) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
|  | mild (n = 3) | 199 ± 52* | 220 ± 77†| 27 ± 8.9†| 17.9 ± 7.4†| 30 ± 13.3†| 22.8 ± 7.9†| |||
|  | With (n = 18) | 519 ± 79 | 3854 ± 88 | 29 ± 6.4 | 32.2 ± 5.8 | 52 ± 7.4 | 41 ± 2.9 | |||
Heart Failure (n = 18/60) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
|  | Without (n = 42) | 476 ± 68‡ | 87 ± 74§ | 22 ± 7.0§ | 29 ± 8.5§ | 44 ± 10.6§ | 33 ± 9.5§ | |||
|  | With (n = 25) | 379 ± 55 | 292 ± 67 | 39 ± 4.0 | 32.3 ± 6.0 | 43 ± 9.9 | 43 ± 8.2 | |||
Cardiomegaly (n = 25/60) | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
|  | Without (n = 35) | 294 ± 95‡ | 201 ± 77§ | 27 ± 6.1§ | 30 ± 4.9§ | 42 ± 12§ | 36 ± 7.0§ | |||