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Table 5 Serum levels of VEGF, PD-ECGF/TP activity and leptin in patients groups in relation to PH, severity of PS, presence or absence of heart failure and cardiomegaly

From: Angiogenic biomarkers in children with congenital heart disease: possible implications

Biomarkers VEGF (pg/ml) PD-ECGF (U/ml) Leptin (ng/ml)
Studied
parameters
  Cyanotic
(n = 30)
Acyanotic
(n = 30)
Cyanotic
(n = 30)
Acyanotic
(n = 30)
Cyanotic
(n = 30)
Acyanotic
(n = 30)
  With (n = 12) 589 ± 89 395 ± 78 39.6 ± 4.4 30 ± 6.0 59.5 ± 6.0 44.6 ± 6.1
PH
(n = 12/60)
          
  Without (n = 48) 276 ± 92* 187 ± 85* 22.2 ± 7.3† 19.9 ± 5.7† 30.2 ± 11† 23.8 ± 5.1†
  Severe (n = 21) 478 ± 74 384 ± 62 47.3 ± 6.6 33 ± 8.9 53.6 ± 8.4 41 ± 6.5
PS
(n = 24/60)
          
  mild (n = 3) 199 ± 52* 220 ± 77† 27 ± 8.9† 17.9 ± 7.4† 30 ± 13.3† 22.8 ± 7.9†
  With (n = 18) 519 ± 79 3854 ± 88 29 ± 6.4 32.2 ± 5.8 52 ± 7.4 41 ± 2.9
Heart Failure
(n = 18/60)
          
  Without (n = 42) 476 ± 68‡ 87 ± 74§ 22 ± 7.0§ 29 ± 8.5§ 44 ± 10.6§ 33 ± 9.5§
  With (n = 25) 379 ± 55 292 ± 67 39 ± 4.0 32.3 ± 6.0 43 ± 9.9 43 ± 8.2
Cardiomegaly
(n = 25/60)
          
  Without (n = 35) 294 ± 95‡ 201 ± 77§ 27 ± 6.1§ 30 ± 4.9§ 42 ± 12§ 36 ± 7.0§
  1. *: p < 0.001
  2. †: p < 0.01
  3. ‡: p < 0.05
  4. §: not significant