Renal functions in pediatric patients with beta-thalassemia major: relation to chelation therapy: original prospective study

Table 5 Correlation coefficient (r) among various parameters in β-thalassaemia major (βTM) pediatric patients.

Parameters	Duration of disease	Age	BMI	S_CysC	S_Cr	S_TAC	S_UA	S_Ca	S_PO4	eGFR	U_NAG/Cr	U_B2MG/Cr	U_MDA/Cr
Age	0.941***
BMI	0.387**	0.356**
S _CysC	0.168	0.101	0.046
S _Cr	0.051	-0.078	‐0.027	0.659***
S _TAC	0.161	0.042	0.193	-0.293*	-0.309**
S _UA	0.073	0.002	-0.091	0.142	0.319**	-0.077
S _Ca	-0.101	-0.077	-0.047	0.091	-0.169	0.105	0.078
S _PO4	0.054	0.023	0.055	0.150	0.339**	0.212	0.055	-0.325**
eGFR	0.229	0.374**	0.097	-0.517**	-0.892***	0.312**	-0.349**	0.144	-0.298*
U _NAG/Cr	0.070	0.144	-0.021	0.141	0.159	0.014	0.220	0.020	0.020	-0.083
U _B2MG/Cr	0.036	0.117	-0.081	0.094	0.0161	-0.018	0.349**	-0.076	0.076	-0.096	0.900***
U _MDA/Cr	0.010	0.068	-0.072	0.142	± 0.188	0.041	0.251*	0.023	0.108	-0.091	0.853***	0.861***
U _albumin/Cr	0.089	0.088	-0.105	0.071	0.146	0.024	0.339**	-0.084	0.085	-0.088	0.885***	0.991***	0.845***

Significance: *: P < 0.05; **: P < 0.01; ***: P < 0.001
BMI, body mass index; S_CysC, serum cystatin-C; S_Cr, serum creatinine, S_TAC, serum total antioxidant capacity; S_UA, serum uric acid; S_Ca, serum calcium; S_PO4, serum inorganic phosphorus; eGFR, estimated glomerular filtration rate; U_NAG/Cr, urinary N-acetyl-beta-D-glucosaminidase to creatinine; U_B2MG/Cr, urinary β₂-microglobulin to creatinine; U_MDA/Cr, urinary malondialdehyde to creatinine; U_albumin/Cr, urinary albumin to creatinine.

ISSN: 1824-7288