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Table 4 Comparison of clinical, laboratory and radiological data of studied cases (n = 50) before and 3 months after Zn supplementation

From: Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

  Before Zn After Zn z p
Height SDS −3.12 ± 0.2 −1.87 ± 0.1 6.76 0.033*
(−2.15- -4.21) (−2.0- -3.11)   
Weight SDS -1.88 ± 0.62 -1.72 ± 0.51 1.83 0.21
(-2.01- +0.55) (-2.05- + 0.66)   
BMI (kg/m2) 16.41 ± 0.56 16.58 ± 0.22 1.59 0.11
(14.33-18.12) (14.91-18.42)   
BMI SDS -1.77 ± 0.41 -1.58 ± 0.32 1.80 0.26
(-2.10- -0.78) (-0.91- -1.95)   
Serum Zn (μg/dl) 56.76 ± 7.9 148.25 ± 15.4 8.29  <0.001***
(37.52-93.11) (77.55-226.13)   
Peak GH after insulin stimulation (ng/ml) 10.65 ± 2.01 12.10 ± 1.13 2.10 0.081
(7.61-13.20) (8.90-14.82)   
Peak GH after clonidine stimulation (ng/ml) 11.14 ± 1.41 12.99 ± 1.22 1.15 0.090
(6.92-14.11) (8.90-14.82)   
IGF-1 (ng/ml) 96.72 ± 11.5 177.50 ± 9.06 7.12 <0.010**
(36.52-115.69) (42.65-213.66)   
IGF-1 SDS -2.46 ± 0.11 -0.91 ± 0.43 9.16 <0.010**
(-3.22- +0.55) (-2.95 - +1.10)   
IGFBP-3 (ng/ml) 2436.12 ± 392 2856.30 ± 411 5.90 0.042*
(1195.45-3898.15) (1341.10-3912.51)   
-BA (years) 3.7 ± 1.05 4.12 ± 1.32 1.25 0.081
(1.81-9.25) (2.13-9.81)   
-BA SDS -1.7 ± 1.14 -1.5 ± 1.21 0.13 0.35
(-2.44 - +0.22) (-2.10- + 0.65)   
  1. Results are expressed as mean ± SD and range, *p < 0.05, **p < 0.01, ***p < 0.001, Zn: zinc, SDS: Standard deviation score, BMI: Body mass index, GH: Growth hormone, IGF-1: Insulin like growth factor-1, IGFBP-3: Insulin like growth factor binding protein-3, BA: bone age.