Figure 2From: Interleukin 12 receptor deficiency in a child with recurrent bronchopneumonia and very high IgE levelsgene sequencing of IL-12R β2 gene. At molecular level, gene sequencing of IL-12R β2 gene revealed a missense mutation (G to A) at nucleotide 531 in the exon 5 in heterozygosity, resulting in the substitution of arginine ( CGT) with histidine (CAT) in the extracellular domain of the receptor at the same aminoacid position 156 (designed R156H).Back to article page