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Table 1 Main causes of primary adrenal failure

From: Acute adrenal failure as the presenting feature of primary antiphospholipid syndrome in a child

Congenital CAH
  Congenital adrenal hypoplasia
  ACTH resistance
  Glucocorticoid resistance
  Metabolic diseases (Adrenoleukodystrophy, Zellweger, Smith-Lemli-Opitz, Wolman disease)
Acquired Autoimmune adrenalitis
  - Isolated
  - Autoimmune polyendocrinopathy
  - syndrome type 1
  - Autoimmune polyendocrinopathy syndrome type 2
  Hemorrhage/infarction
  - Trauma
  - Waterhouse-Frederickson syndrome
  - Anticoagulation
  - Thrombosis (APS, Thrombophilia)
  Drug effects (Aminoglutethimide, mitotane, ketoconazole, medroxyprogesterone)
  Infection
  - Viral: HIV, cytomegalovirus
  - Fungal: coccidiomycosis, histoplasmosis, blastomycosis, cryptococcosis
  - Mycobacterial: tuberculosis
  - Amebic
  Infiltrative (Hemochromatosis, histiocytosis, sarcoidosis, amyloidosis, neoplasm)