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Table 4 Comparison between disease severity score, response to colchicine therapy, and number of attacks per year in the three study groups

From: The expanded clinical profile and the efficacy of colchicine therapy in Egyptian children suffering from familial mediterranean fever: a descriptive study

Item Hetero-zygous (n=40) Homo-zygous (n=20) Gene-ve (n=10) P-value
Disease severity score, n (%) Mild 9 (22.5) 0 (0.0) 0 (0.0) 0.01*
Moderate 26 (65.5) 14 (70) 10 (100)
Severe 5 (12.5) 6 (30) 0 (0.0)
Response to colchicine, n (%) Complete 13 (32.5) 1 (5.0) 2 (20) 0.09
Incomplete 25 (62.5) 19 (95.0) 8 (80)
No response 2 (5) 0 (0.0) 0 (0.0)
Colchicine dose to control attacks, mean ± SD 1.26 ± 0.36 1.47 ± 0.34 1.40 ± 0.21 0.04*
Number of attacks per year, mean ± SD Before treatment (range) 23.70 ± 11.47 (10–72) 24.40 ± 6.95 (12–36) 25 ± 9.76 (16–48) 0.6
After treatment (range) 4.80 ± 5.81 (0–24) 3.95 ± 2.50 (0–10) 4.5 ± 4.22 (0–12) 0.9
  1. *P-value less than 0.05 is considered statistically significant.