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Table 3 Comparison of selected factors between the group of ELBW infants with and without wheeze in the last year

From: The prevalence and risk factors of allergic and respiratory symptoms in a regional cohort of extremely low birth weight children (<1000 g)

  Without wheeze in last year (n=55) Wheeze in the last year (n=26) p value
Perinatal factors
Birth weight (g), mean (SD) 853±139 830±159 0.8a
Gestational age (weeks), mean (SD) 27.3±2.1 27.3±2.6 0.9a
Female 37 (67%) 15 (58%) 0.5b
Length of mechanical ventilation (Me; 25-75th percentile) (days) 17 (2–48) 24 (6–39) 0.8c
Length of oxygen therapy (Me; 25-75th percentile) (days) 44 (13–77) 55 (34–74) 0.9c
Oxygen therapy at least 28 days 34 (62%) 19 (73%) 0.5b
Oxygen therapy at the 36 PMA 21 (38%) 10 (38%) 1.0b
Infancy
Wheeze in the first 24 months of life 29 (53%) 21 (81%) 0.03b
Hospitalization in the first 24 months of life 25 (45%) 19 (73%) 0.03b
Immunoprophylaxis with palimivizumab 8 (15%) 2 (8%) 0.5b
Atopy
Parental history of atopy 9 (17%) 5 (22%) 0.8b
Passive smoking 4 (7%) 4 (15%) 0.26b
Pets at home 21 (40%) 11 (48%) 0.7b
serum tIgE (Me; 25-75th percentile) 22 (12–68) 34 (12–73) 0.3c
Absoulte eosinophil count (eos/uL 230±137 338±275 0.03a
Positive SPT 4 (7%) 4 (15%) 0.26b
Recent status
Hospitalization in the last year 2 (4%) 12 (46%) <0.01b
Current medications 11 (20%) 15 (58%) 0.002b
FEV1 (%) 80±13 83±16 0.61a
Δ%FEV1 (%) 1±7 16±13 0.002a
Δ%FEV1 >12% 0/14 4/8 (50%) 0.01b
  1. p value for ANOVAa, chi square testb, and Kruskal-Wallis test.
  2. ELBW – extremely low birth weight.