Nijmegen breakage syndrome and chronic polyarthritis

Table 1 Immunologic investigations in our patent

	At diagnosis	At the onset of arthritis	Normal values for given age
IgA (g/l)	0.08	0.07	0.11-2.51
IgM	0.04	0.06	0.13-2.51
IgG	0.70	10.8^b	6.54-15.94
IgE (IU/ml)	< 50	-
Absolute lymphocyte count (mm³)	1512	1340	1100-5900
CD3+ lymphocytes	726	650	700-4200
CD4+	333	252	300-2000
CD8+	348	396	300-1800
CD19+	36	42	200-1600
CD3-CD16 + C56+ (NK-cells^a)	665	720	9-900
Proliferative lymphocyte response using phytohemagglutinin (PHA)	Pt. SI^c 18×	-	-
	Control SI 87×

^a NK-cells – natural killer; ^b IgG trough level during replacement therapy with IVIG; ^cSI stimulation index.

ISSN: 1824-7288