Is there a role for high dose chemotherapy and blood stem cell rescue in childhood hepatoblastoma presenting with lung metastases? A case report and literature review

Table 1 High dose chemotherapy with blood stem cell rescue following post-operative chemotherapy for metastatic HB patients achieving partial response after pre-operative chemotherapy

Reference and number of patients	Age/Sex	PRETEXT	Previous regimen	Tumor status at the time of HDCT	Conditioning regimen	BSC source	Outcome
Matsunaga T [19]: 4 patients	Unknown	Any PRETEXT M+	CDDP, THP-ADR	AFP↑	CARBO, VP16, MLP	PB	3 NED 16 mts after BSC rescue 1 DoD
Nishimura SI [15]: 1 patient	10 yr/M	IV M+	CDDP, DOXO	NED	DOXO, VP16, CARBO, 5-FU	BM	NED 6 yr after BSC rescue
Provenzi M 2013: 1 patient	3 yr/M	II M+	CDDP, DOXO	NED	CARBO, VP16, MLP	PB	NED 27 mts after BSC rescue

Abbreviations: BSC blood stem cell, M + lung metastases, CDDP cisplatin, THP-ADR THP-adriamicin, AFP alpha-feto protein, CARBO carboplatin, VP16 etoposide, MLP melphalan, PB peripheral blood, NED no evidence of disease, mts months, DoD died of disease, yr years, DOXO doxorubicin, 5-FU 5 fluorouracil, BM bone marrow.

ISSN: 1824-7288