Table 1 Univariate statistical analysis with demographic/laboratory variables and cardiac abnormalities in comparison with the FGF23 gene polymorphism in the cohort of 84 children with Kawasaki syndrome recruited for this study
Variable | FGF23 wild gene | FGF23 polymorphism | p value |
|---|---|---|---|
Sex (M/F) | 40/20 | 22/2 | 0.03 |
(66.7%-33.3%) | (91.7%-8.3%) | ||
Age of onset (in months) | 24.5 [13.2-49.5] | 36 [16.7-58.0] | 0.39 |
Fever duration (in days) | 8.7 ± 4.0 | 9.3 ± 3.8 | 0.75 |
Laboratory data | |||
Serum FGF23 | 10.7 ± 13.5 | 41.4 ± 53.9 | 0.01 |
ESR at onset (mm/1 h) | 83.3 ± 22.7 | 83.5 ± 19.4 | 0.44 |
CRP at onset (mg/L) | 14.0 ± 15.8 | 17.3 ± 16.9 | 0.52 |
Hb at onset (g/L) | 10.6 ± 1.1 | 10.2 ± 0.9 | 0.48 |
Platelet count at onset (×109/L) | 450.8 ± 142.1 | 433.0 ± 124.1 | 0.86 |
Fibrinogen at onset (mg/dl) | 672.33 ± 216.6 | 732.6 ± 162.3 | 0.27 |
Total cholesterol (mg/dl) | 162.2 ± 34.0 | 171.8 ± 22.3 | 0.13 |
HDL cholesterol (mg/dl) | 39.5 ± 14.6 | 39.6 ± 12.5 | 0.59 |
LDL cholesterol (mg/dl) | 103.7 ± 39.7 | 105.6 ± 29.6 | 0.44 |
Triglycerides (mg/dl) | 86.5 ± 58.1 | 89.7 ± 76.4 | 0.65 |
Cardiac abnormalities | |||
Coronary dilatations | 6/54 | 7/17 | 0.03 |
(present/absent) | (10.0%/90.0%) | (29.2%/70.8%) | |
Coronary aneurysms | 2/58 | 1/23 | 0.64 |
(present/absent) | (3.3%/96.7%) | (4.2%/95.8%) | |
Coronary aneurysms or dilatations | 7/53 | 7/17 | 0.05 |
(present/absent) | (11.7%/88.3%) | (29.2%/70.8%) | |
Pericardial effusion | 7/53 | 4/20 | 0.54 |
(present/absent) | (11.7%/88.3%) | (16.7%/83.3%) | |
Any cardiac involvement | 14/46 | 10/14 | 0.09 |
(present/absent) | (23.3%/76.7%) | (41.7%/58.3%) | |