Skip to main content

Table 4 Genotype and allele frequencies of the rs1799983 polymorphism of the NOS3 gene in RDS and the control groups among different gestational ages and birth weights

From: Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population

Genotype/Allele Control group (n = 227) RDS group (n = 189) P value OR (95% CI)
Gestational age     
  26w ≤ GA < 33 W n = 80 n = 117   
  GG 33 (41.3) 77 (65.8)   
  GT 45 (56.3) 36 (30.8) 0.001 0.343 (0.188-0.624)
  TT 2 (2.4) 4 (3.4) 1.000 0.857 (0.150-4.911)
  G allele 111 (69.4) 190 (81.2)   
  T allele 49 (30.6) 44 (18.8) 0.007 0.525 (0.328-0.839)
  33w ≤ GA < 37 W n = 147 n = 72   
  GG 101 (68.7) 50 (69.4)   
  GT 43 (29.3) 21 (29.2) 1.000 0.987 (0.530-1.838)
  TT 3 (2.0) 1 (1.4) 1.000 0.673 (0.068-6.639)
  G allele 245 (83.3) 121 (84.0)   
  T allele 49 (16.7) 23 (16.0) 0.892 0.950 (0.553-1.633)
Birth weight     
  BW < 1.5 n = 21 n = 64   
  GG 10 (47.6) 44 (68.8)   
  GT 11 (52.4) 15 (23.4) 0.031 0.310 (0.110-0.875)
  TT 0 (0) 5 (7.8) - -
  G allele 31 (73.8) 103 (80.5)   
  T allele 11 (26.2) 25 (19.5) 0.387 0.684 (0.303-1.545)
  1.5 < BW < 2.5 n = 105 n = 106   
  GG 73 (69.5) 71 (67.0)   
  GT 30 (28.6) 35 (33.0) 0.554 1.200 (0.667-2.157)
  TT 2 (1.9) 0 (0) - -
  G allele 176 (83.8) 177 (83.5)   
  T allele 34 (16.2) 35 (16.5) 1.000 1.024 (0.611-1.715)
  BW > 2.5 n = 101 n = 19   
  GG 51 (50.5) 12 (63.2)   
  GT 47 (46.5) 7 (36.8) 0.455 0.633 (0.230-1.743)
  TT 3 (3.0) 0 (0) - -
  G allele 149 (73.8) 31 (81.6)   
  T allele 53 (26.2) 7 (18.4) 0.414 0.635 (0.264-1.527)