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Table 4 Genotype and allele frequencies of the rs1799983 polymorphism of the NOS3 gene in RDS and the control groups among different gestational ages and birth weights

From: Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population

Genotype/Allele

Control group (n = 227)

RDS group (n = 189)

P value

OR (95% CI)

Gestational age

    

  26w ≤ GA < 33 W

n = 80

n = 117

  

  GG

33 (41.3)

77 (65.8)

  

  GT

45 (56.3)

36 (30.8)

0.001

0.343 (0.188-0.624)

  TT

2 (2.4)

4 (3.4)

1.000

0.857 (0.150-4.911)

  G allele

111 (69.4)

190 (81.2)

  

  T allele

49 (30.6)

44 (18.8)

0.007

0.525 (0.328-0.839)

  33w ≤ GA < 37 W

n = 147

n = 72

  

  GG

101 (68.7)

50 (69.4)

  

  GT

43 (29.3)

21 (29.2)

1.000

0.987 (0.530-1.838)

  TT

3 (2.0)

1 (1.4)

1.000

0.673 (0.068-6.639)

  G allele

245 (83.3)

121 (84.0)

  

  T allele

49 (16.7)

23 (16.0)

0.892

0.950 (0.553-1.633)

Birth weight

    

  BW < 1.5

n = 21

n = 64

  

  GG

10 (47.6)

44 (68.8)

  

  GT

11 (52.4)

15 (23.4)

0.031

0.310 (0.110-0.875)

  TT

0 (0)

5 (7.8)

-

-

  G allele

31 (73.8)

103 (80.5)

  

  T allele

11 (26.2)

25 (19.5)

0.387

0.684 (0.303-1.545)

  1.5 < BW < 2.5

n = 105

n = 106

  

  GG

73 (69.5)

71 (67.0)

  

  GT

30 (28.6)

35 (33.0)

0.554

1.200 (0.667-2.157)

  TT

2 (1.9)

0 (0)

-

-

  G allele

176 (83.8)

177 (83.5)

  

  T allele

34 (16.2)

35 (16.5)

1.000

1.024 (0.611-1.715)

  BW > 2.5

n = 101

n = 19

  

  GG

51 (50.5)

12 (63.2)

  

  GT

47 (46.5)

7 (36.8)

0.455

0.633 (0.230-1.743)

  TT

3 (3.0)

0 (0)

-

-

  G allele

149 (73.8)

31 (81.6)

  

  T allele

53 (26.2)

7 (18.4)

0.414

0.635 (0.264-1.527)