Table 1 Patients’ clinical features and laboratory results
Characteristics | Patient #1 | Patient #2 |
|---|---|---|
Sex | Female | Male |
Age at diagnosis | 13 years | 20 months |
Peripheral blood: | ||
Hb (g/dL) | 9.8 | 12 |
White blood cells count (μL) | 7,870 | 14,390 |
Eosinophils count (μL)(%) | 3,490 (44.3%) | 4,620 (32.1%) |
Platelets count (μL) | 129,000 | 223,000 |
Blasts (%) | None | 2 |
Bone marrow aspirate: | ||
Blasts (%) | 52 | 60 |
Eosinophils (%) | 30 | 36 |
FAB classification | L2 | L1 |
Immunophenotype | Common | Common |
DNA index | 1 | 1,1 |
Bone marrow biopsy | B cells lymphoproliferative syndrome; MF1 (WHO grading) | B cells lymphoproliferative syndrome; MF0 (WHO grading) |
Karyotype | 46, XX | Hyperdiploid (52,XXY,+6,+14,+17,+21,+21[5]) |
Molecular biology for ALL rearrangements | Negative | Negative |
Molecular biology for thrombophilia | Positive (Homozygous for -455G/A of b-fibrinogen) | Positive (Eterozygous for P1b of HPA) |
Clinical presentation | Evening fever | Night sweat |
Left iliac-femoral deep venous thrombosis | Fever | |
Pruritic erythroderma | ||
Claudication for left inferior limb arthralgia | ||
Other organ involvement | No | Skin |
Bone (tibial osteolysis) |