Author | Population study | Sample | Metabolomic analysis | Metabolite alterations |
---|---|---|---|---|
Fanos et al. 2014 | 9 septic newborns vs 16 control newborns | Urine | GC-MS 1H NMR | Lactate, glucose, maltose, ribitol, ribonic acid, pseudo-uridine, 2,3,4 trihydroxybutiric acid, 2-ketpgluconic acid, 3,4 hydroxybutanoic acid, 3,4,5 trihydroxypentanoic acid <(GC-MS) Acetate, acetone, citrate, creatinine, glycine, lactate, lysine, glucose (1H-NMR) |
Mickiewicz et al. 2013 | 60 septic shock vs 40 SIRS vs 40 control pediatric patients | Serum | 1H-NMR | 2-hydroxybutyrate, 2-hydroxyisovalerate, lactate, glucose, 2-oxoisocaproate, creatine, creatinine, histidine, and phenylalanine |
Schmerler et al. 2012 | 74 SIRS vs 69 septic vs 16 control human adults | Blood | LC-MS/MS | Acylcarnitines and glycerophosphatidylcholines |
Mickiewitz et al. 2014 | 39 septic shock adult patients vs 20 ICU control patients | Serum | 1H-NMR | Isobutyrate, phenylalanine, 2 hydroxyisovalerate, myoinositol, acetylcarnitine, creatine, lactate, valine, arginine, methanol, glucose, glycine |
Liu et al. 2010 | 40 septic vs control rats | Plasma | UPLC–Q-TOF-MS | Hypoxanthine, indoxyl sulfate, glucuronic acid, gluconic acid, proline, uracil, nitrotyrosine, uric acid and trihydroxy cholanoic acid |
Lin et al. 2009 | 40 septic vs 20 control rats | Serum | 1H NMR | Lactate, alanine, acetate, acetoacetate, hydroxybutyrate and formate |
Izquierdo-Garcìa et al. 2011 | 14 septic vs 14 control rats | Lung tissue, BALF and serum | 1H NMR | Alanine, creatine, phosphoethanolamine and myoinositol |