Figure 1

The immunotherapy’s triad. The main routes and forms of immunotherapy. Due to the complexity of IgE mediated disorders the triad could be considered as complementary therapy. Thus SCIT, SLIT and OIT could be used in various combination and timing in order to optimize both adherence to treatment and therapeutics effect. SCIT= subcutaneous immunotherapy for the treatment of allergic asthma and allergic rhinitis. SLIT= sublingual immunotherapy for the treatment respiratory allergies and IgE mediated food allergies. OIT= oral immunotherapy for the active treatment of IgE mediated food allergy. On the horizon: the treatment of extrinsic form IgE mediated atopic dermatitis.