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Table 2 Characteristics of patients at hospital admission and treatment by causative agent

From: In-hospital management of children with bacterial meningitis in Italy

  N. meningitidis S. pneumoniae Other Not known p-value Total
  N. (29) N. (17) N. (10) N. (29)   N. (85)
Median age at onset yrs - (IQR) 4.0 (1.5 - 7.6) 1.4 (0.5 - 4.6) 0.6 (0.3 - 7.0) 5.2 (0.4 - 8.2) 0.085 3.3 (0.5 - 7.1)
Median interval days between onset and hospital admission - (IQR) 1 (1-2) 3 (2-3) 1 (0-2) 1 (1-4) 0.005 1 (1-3)
Number of patients treated with antibiotics prior to hospitalization - (%) 14 (48.3) 8 (47.1) 2 (20.0) 18 (62.1) 0.238 42 (49.4)
Median interval hours between suspected diagnosis of meningitis and first in-hospital antibiotic administration - (IQR) 1 (1-2) 1 (1-2) 1 (1-2) 1 (1-2) 0.995 1 (1-2)
In vitro susceptibility testing available <3 days since admission, excluded unknown agent - (%) 22 (75.9) 12 (70.6) 8 (80.0) - 0.691 42 (75.0)
Type of antibiotic administered - (%)      <0.001  
III-generation cephalosporin 18 (62.1) 2 (11.8) 1 (10.0) 16 (55.2)   29 (34.1)
III-generation cephalosporin + glycopeptides 3 (10.3) 7 (41.2) 1 (10.0) 1 (3.4)   17 (20.0)
III-generation cephalosporin + other antibiotics 8 (27.6) 8 (47.1) 5 (50.0) 11 (37.9)   10 (11.8)
Other 0 (0.0) 0 (0.0) 3 (30.0) 1 (3.4)   29 (34.1)
Number of patients treated with dexamethasone - (%) 15 (51.7) 14 (82.4) 6 (60.0) 19 (65.5) 0.222 54 (63.5)
Number of patients who received dexamethasone within 1 hour of antibiotic - (%) 9 (31.0) 10 (58.8) 5 (50) 10 (34.5) 0.544 34 (40)
Median duration days of dexamethasone treatment - (IQR) 6 (4-12) 4 (4-12) 7 (4-11) 6 (4-10) 0.951 6 (4 - 12)
  1. IQR: interquartile range.