Figure 11From: Molecular physiopathogenetic mechanisms and development of new potential therapeutic strategies in persistent pulmonary hypertension of the newborn Role of Endothelin in the pathogenesis of pulmonary vascular remodeling in organic PPHN. In animal models of PPHN the negative effect of superoxide can be counteracted by Nitric oxide-donors and L-citrulline enhancing, respectively, exogenous and endogenous Nitric oxide bioavailability (see text).Back to article page