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Table 1 Factor IX desensitization protocol (modified from Dioun et al. [12])

From: Desensitization and immune tolerance induction in children with severe factor IX deficiency; inhibitors and adverse reactions to replacement therapy: a case-report and literature review

 

Dose (U/kg)

Cumulative dose (U/kg)

Infusion time

Interval from previous dose (min)

Day 1

0.01

0.01

5 min

0

0.02

0.03

5 min

10

0.04

0.07

5 min

10

0.08

0.15

5 min

10

0.10

0.25

5 min

10

0.02

0.45

5 min

20

0.04

0.85

5 min

20

0.08

1.65

5 min

20

1.5

3.15

5 min

20

3

6.15

30 min

-

6

12.15

30 min

-

9

21.15

60 min

-

10

31.15

60 min

-

Day 2

40

40

10 h

-

Day 3

40

40

8 h

-

Day 4

40

40

6 h

-

Day 5

40

40

4 h

-

Day 6

40

40

2 h

-

Day 7

40

40

1 h

-

Day 8

40

40

30 min

-

Day 9

40

40

20 min

-