Table 2 Summary of outcomes of selected studies
From: Early and late Iron supplementation for low birth weight infants: a meta-analysis
Serum ferritin (ng/mL) | Hemoglobin (g/dL) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Study # | 1st AU (year) | Group | number of evaluated subject | before | after | before | after | Blood transfusion (%) | Necrotizing enterocolitis (>bell stage 2) |
1 | Joy [17] | early | 46 | 112 ± 5 at 2 weeks of age | 82 ± 5 | 12.9 ± 0.8 at 2 weeks of age | 10.1 ± 0.4 | 2 (4.3%) | 3/46 |
late | 47 | 113 ± 6 at 2 weeks of age | 63 ± 3 | 13.1 ± 0.6 at 2 weeks of age | 9.2 ± 0.4 | 7 (14.8%) | 4/47 | ||
2 | Sankar [18] | early | 22 | 55.7 ± 12.1 at enrollment | 50.8 ± 11.5 | na | na | 2 (9.5%) | 1/21 |
late | 24 | 59.0 ± 12.1 at enrollment | 45.3 ± 11.9 | 3 (13.0%) | 0/23 | ||||
3 | Arnon [19] | early | 32 | 94 ± 27 at 2 weeks of age | 46 ± 20 at 8 weeks of age | 12.5 ± 0.9 at 2 weeks of age | 9.0 ± 1 at 8 weeks of age | 1/33 (2.8%) | 1/32 |
late | 36 | 90 ± 21 at 2 weeks of age | 30 ± 12 at 8 weeks of age | 11.9 ± 1.3 at 2 weeks of age | 7.4 ± 0.7 at 8 weeks of age | 10/46 (21.3%) | 3/36 | ||
4 | Franz [21] | early | 68 | 85.5 (18, 282) *at birth | 87.8 (9, 478)* | na | na | 41/105 (39.0%) | 6/105 |
late | 65 | 77.9 (13, 354)*at birth | 74.2 (9, 682)* | 53/99 (53.5%) | 8/99 | ||||
5 | Jansson [20] | early | 15 | 102 (34–220)*at 1–2 days of age | 56 (16–175)* at 8–10 weeks of age 26 (18–45)* at 6 months of age | 20.0 ± 2.7 at birth | 10.3 ± 1.0 at 8–10 weeks of age; 11.5 ± 0.7 at 6 monthsof age | na | na |
late | 13 | 1-2 days: 100 (45–200)*at 1–2 days of age | 72 (21–170)* at 8–10 weeks of age 28 (10–115)* at 6 months of age | 19.1 ± 2.9 at birth | 9.7 ± 1.0 at 8–10 weeks of age 11.5 ± 0.5 at 6 months of age | ||||