Figure 2

Histological images of skin biopsy revealing a granulomatous inflammatory process. The microphotograph shows a severely damaged epidermis due to a dense inflammatory process obliterating the entire dermis, mainly composed of histiocytes with an epithelioid appearance and lymphocytes arranged in a granulomatous pattern (a). The immunostaining for CD68 shows positivity in the vast majotity of infiltrating cells (b). A few multinucleated giant cell of Langhans type are present (c, insert) which are positive for CD 68 (d, insert). a) HE 10 x; b) Immunostaining 20 x; c) HE 40 x; d) Immunostaining 40 x.