Table 1 Patients with Dent-1 disease in the absence of hypercalciuria reported in the literature
From: Nephrotic-range Albuminuria as the presenting symptom of Dent-2 disease
Parameters | Patient 1 [5] | Patient 2 [5] | Patient 3 [5] | Patient 4 [5] | Patient 5 [6] | Patient 6 [7] | Patient 7 [7] | Patient 8 [8] | Patient 9 [8] | |
|---|---|---|---|---|---|---|---|---|---|---|
Age (years) | 9 | 11 | 14 | 9 | 9 | 6 | 6 | 36 | 15 | |
CrCl (cc/min/1.73 m2) | >90 | 97 | 105 | 95.5 | 126 | 79 | 98 | 135 | >80 | >80 |
S-Alb (gr/dl) | 3.5-5.3 | 4.5 | 4.9 | 4.1 | 4.4 | 4.6 | 4.5 | 4.9 | - | - |
U-prot (mg/day) | <200 | 800–1000 | 600–1400 | 750–1100 | 1240 | 1321 | – | - | - | - |
U-prot/U-Cr (mg/mg) | <0.2 | - | - | - | - | - | 3.4 | 2.6 | - | - |
U-β2MG (mg/l) | < 10 | 91.2 | 103 | 120 | 74.4 | 52.7 | - | - | >10 | >10 |
U-β2MG (mcg/g cr) | < 132 | 166.1 | >132 | >132 | ||||||
U-Ca/U-Cr (mg/mg) | < 0.5 for 1-3y | 0.15 | 0.14 | 0.13 | 0.12 | 0.07 | 0.18 | 0.10 | < 0.25 | < 0.25 |
<0.4 for 3-5 y | ||||||||||
<0.3 for 5-7 y | ||||||||||
< 0.25 for >7y | ||||||||||
U-gluc | absent | neg | neg | neg | neg | - | - | - | - | - |
TRP (%) | 82-95 | 87.4 | 91.8 | 86.2 | 95.8 | 85 | - | - | - | |
Nephrocalcinosis by Renal US | Yes | Yes | No | No | No | No | Yes | No | No |