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Table 1 Patients with Dent-1 disease in the absence of hypercalciuria reported in the literature

From: Nephrotic-range Albuminuria as the presenting symptom of Dent-2 disease

Parameters   Patient 1 [5] Patient 2 [5] Patient 3 [5] Patient 4 [5] Patient 5 [6] Patient 6 [7] Patient 7 [7] Patient 8 [8] Patient 9 [8]
Age (years)   9 11 14 9 9 6 6 36 15
CrCl (cc/min/1.73 m2) >90 97 105 95.5 126 79 98 135 >80 >80
S-Alb (gr/dl) 3.5-5.3 4.5 4.9 4.1 4.4 4.6 4.5 4.9 - -
U-prot (mg/day) <200 800–1000 600–1400 750–1100 1240 1321 - - -
U-prot/U-Cr (mg/mg) <0.2 - - - - - 3.4 2.6 - -
U-β2MG (mg/l) < 10 91.2 103 120 74.4 52.7 - - >10 >10
U-β2MG (mcg/g cr) < 132       166.1   >132 >132
U-Ca/U-Cr (mg/mg) < 0.5 for 1-3y 0.15 0.14 0.13 0.12 0.07 0.18 0.10 < 0.25 < 0.25
<0.4 for 3-5 y
<0.3 for 5-7 y
< 0.25 for >7y
U-gluc absent neg neg neg neg - - - - -
TRP (%) 82-95 87.4 91.8 86.2 95.8   85 - - -
Nephrocalcinosis by Renal US   Yes Yes No No No No Yes No No
  1. CrCl creatinine clearance, S-Alb serum albumin, U-prot urinary protein, U-β2MG urinary beta2microglobuline, U-Ca/U-Cr urinary calcium/urinary creatinine, U-prot/U-Cr urinary protein/urinary creatinine, U-gluc urinary glucose, TRP tubular reabsorption of phosphate, Renal US renal ultrasound