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Table 3 Fat-soluble vitamin supplementation in the cholestatic infant

From: Italian guidelines for the management and treatment of neonatal cholestasis

Vitamin Preparation Dosage Adverse effects
Vitamin A Aquasol A 5000-25000 U/day per os Hepatotoxicity, Hypercalcemia,
Vitamin D Cholecalciferol 800-5000 U/day PO per os Hypercalcemia, Nephrocalcinosis
Vitamin E D-α-tocopheryl polyethylene glycol 1,000 succinate 15-25 U/kg/day PO per os Potentiation of vitamin K deficiency coagulopathy
Vitamin K Phytomenadione 2.5–5 mg twice a week to every day per os