The effects of selective head cooling versus whole-body cooling on some neural and inflammatory biomarkers: a randomized controlled pilot study

Table 3 Biomarker levels at 6 h

Biomarkers	SHC group (n = 14)	WBC group (n = 10)	Mild HIE group (n = 7)	Control group (n = 9)
IL-6 (pg mL⁻¹)	49.5^a (15.8–219.9)	46.7^a (33.1–413.5)	24.7^a,b (14.0–69.6)	3.8^b (2.8–6.6)
IL-1β (pg mL⁻¹)	2.2 (2.1–2.3)	2.5 (2.1–3.0)	2.1 (2.0–2.6)	2.1 (2.0–2.2)
TNF-α (pg mL⁻¹)	15.2 (10.8–25.6)	15.8 (13.7–41.6)	20.3 (13.9–25.6)	15.3 (13.1–24.4)
NSE (μg L⁻¹)	0.58 (0.44–1.62)	0.67 (0.48–2.65)	0.49 (0.37–2.13)	0.45 (0.36–0.51)
S100B (ng mL⁻¹)	0.08 (0.07–0.09)	0.12 (0.07–0.15)	0.11 (0.08–0.15)	0.07 (0.06–0.08)
S100 (ng L⁻¹)	17.5^a (5.6–60.4)	15.3^a (7.7–86.9)	1.7^a,b (0.8–25.6)	1.9^b (0.7–4.7)
CKBB (ng mL⁻¹)	1.9 (1.5–3.0)	2.1 (1.4–3.9)	1.9 (1.4–2.3)	1.4 (1.1–1.8)
L/C ratio	9.24^a (1.32–43.89)	3.00^a (0.82–34.60)	0.05^b (0.03–0.11)	0.04^b (0.03–0.08)

Data shown as median (IQR)
^a and ^b denote differences between groups, according to post hoc test. There is a significant difference data shown with different letters (P < 0.05)

ISSN: 1824-7288