The effects of selective head cooling versus whole-body cooling on some neural and inflammatory biomarkers: a randomized controlled pilot study

Table 4 Biomarker levels at 72 h

Biomarkers	SHC group (n = 14)	WBC group (n = 10)	Mild HIE group (n = 7)	Control group (n = 9)
IL-6 (pg mL⁻¹)	64.2^a (30.4–118.0)	43.0^a (33.1–416.0)	4.3^b (1.2–17.6)	3.0^b (1.3–6.0)
IL-1β (pg mL⁻¹)	2.2 (2.0–2.3)	2.2 (2.1–2.6)	2.3 (2.1–2.7)	2.1 (2.0–2.2)
TNF-α (pg mL⁻¹)	19.5 (12.5–41.7)	17.0 (13.3–25.3)	24.3 (20.2–40.6)	15.7 (10.8–16.7)
NSE (μg L⁻¹)	0.51 (0.38–0.74)	0.57 (0.38–1.70)	1.01 (0.40–1.93)	0.38 (0.32–0.47)
S100B (ng/ml	0.08 (0.07–0.15)	0.10 (0.06–0.15)	0.12 (0.07–0.21)	0.08 (0.07–0.12)
S100 (ng L⁻¹)	2.9 (0.5–15.5)	9.5 (0.3–29.8)	1.6 (0.8–3.6)	1.5 (0.4–3.8)
CKBB (ng mL⁻¹)	1.0 (0.6–1.7)	0.8 (0.5–1.5)	0.9 (0.7–1.1)	1.0 (0.8–1.1)
L/C ratio	0.08 (0.04–0.27)	0.06 (0.04–0.16)	0.05 (0.03–0.06)	0.03 (0.02–0.04)

Data shown as median (IQR)
^a and ^b denote differences between groups, according to post hoc test. There is a significant difference data shown with different letters (P < 0.05)

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