Metamorphic thyroid autoimmunity in Down Syndrome: from Hashimoto’s thyroiditis to Graves’ disease and beyond

Table 1 Sex, ages, thyrotropin (TSH), free thyroxine (FT4) and thyroid autoantibody serum levels in the 12 patients of our series at diagnosis of both Hashimoto’s thyroiditis (HT) and Graves’ disease (GD)

Patients	Sex	Age (years)	TSH^a (mU/l)	FT4^b (pmol/l)	TPOAbs^c (IU/ml)	TgAbs^d (IU/ml)	TRABs^e (IU/l)
1	F	HT 3.0	7.10	12.6	95	60	<1.0
1	F	GD 5.5	0.0500	45.1	796	150	23.4
2	F	HT 3.0	19.56	9.9	1310	182	<1.0
2	F	GD 9.0	0.0500	36.8	1300	79	19.0
3	F	HT 3.3	0.07	24.6	57	187	<1.0
3	F	GD 4.0	0.0060	47.8	44	148	85.0
4	M	HT 4.0	8.80	16.8	180	120	<1.0
4	M	GD 9.9	0.0500	66.1	278	199	32.7
5	F	HT 4.0	5.30	12.1	26	28	<1.0
5	F	GD 8.8	0.0001	41.9	149	758	25.2
6	M	HT 5.0	0.05	50.0	284	35	<1.0
6	M	GD 6.1	0.0500	41.6	189	170	22.0
7	F	HT 5.9	5.10	17.4	75	302	<1.0
7	F	GD 11.1	0.0100	31.6	248	55	28.0
8	F	HT 6.0	8.20	10.5	144	104	<1.0
8	F	GD 9.0	0.0500	26.0	39	3	21.0
9	M	HT 8.0	0.01	38.0	278	199	<1.0
9	M	GD 10.0	0.0050	58.7	278	199	32.7
10	M	HT 9.7	9.10	11.0	37	2	<1.0
10	M	GD 13.2	0.0200	29.4	200	200	23.0
11	M	HT 10.0	8.10	10.5	22	119	<1.0
11	M	GD 15.0	0.0010	34.4	45	220	16.0
12	F	HT 13.5	4.30	18.0	23	109	1.0
12	F	GD 20.0	0.0060	25.0	61	117	31.4

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