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Table 3 Incidence of necrotizing enterocolitis in infants treated with probiotics and in controls

From: Probiotics for prevention of necrotizing enterocolitis in preterm infants: systematic review and meta-analysis

Author, year Previous NEC rate Number of subjects NEC in probiotic group NEC in control group
Al-Hosni, 2012 [33] Not stated 50 probiotic 3/50 any stage 4/51 any stage
51 control 1/50 stage 1 2/51 stage 1
0/50 stage 2 0/51 stage 2
2/50 stage 3 2/51 stage 3
Bin-Nun, 2005 [40] 15 % 72 probiotic 3/72 any stage 12/73 any stage
73 control 1/72 stage ≥2 10/73 stage ≥2
1/72 stage 2 7/73 stage 2
0/72 stage 3 3/73 stage 3
Braga, 2011 [35] 10 % 119 probiotic 0/119 stage ≥2 4/112 stage ≥2
112 placebo
Costalos, 2003 [49] Not stated 51 probiotic 5/51 any stage 6/36 any stage
36 placebo
Dani, 2002 [42] Not stated 295 probiotic 4/295 stage ≥2 8/290 stage ≥2
290 placebo
Demirel, 2013 [28] 32 % 135 probiotic 6/135 stage ≥2 7/136 stage ≥2
136 control
Dilli, 2015 [44] Not stated 100 probiotic 2/100 stage ≥2 18/100 stage ≥2
100 placebo
Fernández-Carrocera, 2013 [32] 20 % 75 probiotic 6/75 stage ≥2 12/75 stage ≥2
75 placebo
Jacobs, 2013 [26] Not stated 548 probiotic 11/548 stage ≥2 24/551 stage ≥2
551 placebo
Kitajima, 1997 [52] Not stated 45 probiotic 0/45 any stage 0/46 any stage
46 placebo
Lin, 2005 [41] Approx. 23 % (NEC or death) 180 probiotic 2/180 stage ≥2 10/187 stage ≥2
187 control 2/180 stage 2 4/187 stage 2
0/180 stage 3 6/187 stage 3
Lin, 2008 [37] Approx. 217 placebo 4/217 any stage 14/217 any stage
217 control 2/217 stage 2 9/217 stage 2
2/217 stage 3 5/217 stage 3
Manzoni, 2006 [37] Not stated 39 probiotic 1/39 any stage 3/41 any stage
41 control 1/39 stage 2 2/41 stage 2
0/39 stage 3 1/41 stage 3
Mihatsch, 2010 [43] Not stated 84 probiotic 2/84 stage ≥2 4/82 stage ≥2
82 placebo
Mohan, 2006 [53] Not stated 21 probiotic 2/37 stage ≥2 1/32 stage ≥2
17 placebo Unpublished data, taken from Alfaleh 2011 [58] Unpublished data, taken from Alfaleh 2011 [58]
Oncel, 2013 [25] 15 % 200 probiotic 8/200 stage ≥2 10/200 stage ≥2
200 placebo
Patole, 2014 [45] Not stated 74 probiotic 0/74 stage ≥2 1/66 stage ≥2
66 placebo
Rojas, 2012 [30] Not stated 372 probiotic NEC stage ≥2 NEC stage ≥2
378 placebo ≤1500 g ≤1500 g
6/176 probiotic 10/184 placebo
>1500 g >1500 g
3/196 probiotic 5/194 placebo
Rougé, 2009 [50] Not stated 45 probiotic 2/45 any stage 1/49 any stage
49 placebo
Roy, 2014 [58] Not stated 56 probiotic 2/56 any stage 2/56 any stage
56 placebo
Saengtawesin, 2014 [48] Not stated 31 probiotic 1/31 stage ≥2 1/29 stage ≥2
29 placebo
Samanta, 2009 Not stated 91 probiotic 5/91 stage ≥2 15/95 stage ≥2
95 control
Sari, 2011 [34] Approx. 32 % (death or NEC) 110 probiotic 6/110 stage ≥2 10/111 stage ≥2
111 control 4/110 stage 2 7/111 stage 2
2/110 stage 3 3/111 stage 3
Serce, 2013 [27] 17 % 104 probiotic 7/104 stage ≥2 7/104 stage ≥2
104 placebo
Stratiki, 2007 [39] Not stated 41 probiotic 0/41 stage ≥2 3/34 stage ≥2
34 control
Totsu, 2014 [46] Not stated 153 probiotic 0/153 stage ≥1 0/130 stage ≥1
130 control
  1. NEC necrotizing enterocolitis