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Table 2 Quality assessment (QUADAS)

From: Diagnostic value of soluble triggering receptor expressed on myeloid cells in paediatric sepsis: a systematic review

 

Chen

et al. 2008 [21]

Carrol

et al. 2009 [23]

Sarafidis

et al. 2010 [17]

Kevan

et al. 2011 [22]

Miedema

et al. 2011 [25]

Arzanian

et al. 2011 [24]

Schlapbach et al. 2013 [18]

Mazzucchelli et al. 2013 [19]

Adly

et al. 2014 [20]

Was the spectrum of patients representative of the patients who will receive the test in practice?

+

+

+

Were selection criteria clearly described?

+

+

+

+

+

Is the reference standard likely to correctly classify the target condition?

+

+

+

+

+

+

+

+

+

Is the time period between reference standard and index test short enough to be reasonably sure that the target condition did not change between the two tests?

+

+

+

+

+

+

+

+

+

Did the whole sample or a random selection of the sample, receive verification using a reference standard of diagnosis?

+

+

+

+

?

+

+

+

Did patients receive the same reference standard regardless of the index test result?

+

+

+

+

+

+

+

+

+

Was the reference standard independent of the index test (i.e. the index test did not form part of the reference standard)?

+

+

+

+

+

+

+

+

+

Was the execution of the index test described in sufficient detail to permit replication of the test?

+

+

+

+

+

+

+

+

Was the execution of the reference standard described in sufficient detail to permit its replication?

+

+

+

+

+

+

+

+

Were the index test results interpreted without knowledge of the results of the reference standard?

+

+

+

+

+

+

+

+

+

Were the reference standard results interpreted without knowledge of the results of the index test?

?

?

?

?

?

?

?

?

?

Were the same clinical data available when test results were interpreted as would be available when the test is used in practice?

+

+

+

+

+

+

+

+

+

Were uninterpretable/intermediate test results reported?

+

+

+

+

+

?

+

?

?

Were withdrawals from the study explained?

+

+

+

+

+

?

+

?

?

  1. “+” = low risk of bias; “−” = high risk of bias; “?” = unclear risk of bias