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Table 5 Evaluation of cytogenetic indicator in VOUS suggests that gene density is the only parameter associated to ID

From: New insights in the interpretation of array-CGH: autism spectrum disorder and positive family history for intellectual disability predict the detection of pathogenic variants

 

Intellectual disability

  

Absent (n=4)

Mild/Moderate (n=21)

Total (n=25)

p

Deletion; n (%)

3 (75 %)

10 (47.6 %)

13 (52 %)

0.593

CNV dimension; Median [25th 75th percentile]

367.5 [145.75;801.5]

258 [160.5;791]

258 [160.5;791]

0.902

Genic densitiy; Median [25th 75th percentile]

0.5 [0;1]

2 [1;4.25]

2 [1;3.25]

0.019

Multiple CNVs; Median [25th 75th percentile]

1 [1;2.5]

1 [1;2]

1 [1;2]

0.858