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Table 1 Characteristics of included studies

From: Meta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis

ID

Author

Year

Area

n

Episodes of sepsis

Infected/noninfected

Diagnosis standard

Type of sepsis

Infants

nCD64 analysis

Analysis cut-off

TP

FP

FN

TN

1

Bhandari

2008 [7]

USA

163

293

128/165

Clinical or proven

b

Preterm

FCM

2.30*

90

63

38

102

2

Dilli

2010 [21]

Turkey

109

109

35/74

Clinical or proven

c

Preterm + term

FCM

4.39*

31

11

4

63

3

Genel

2012 [22]

Turkey

119

119

49/70

Clinical or proven

c

Preterm + term

FCM

3.05 MFI

40

16

9

54

4

Groselj-Grenc

2009 [23]

Slovenia

46

46

17/29

Clinical or proven

c

Preterm + term

FCM

1.86*

13

6

4

23

5

Lam

2011 [24]

China

310

310

136/174

Clinical or proven

a

Preterm  + term

FCM

6010 $

107

37

29

137

6

Motta

2014 [25]

Italy

129

129

48/81

Clinical or proven

a

Preterm

FCM

2.4*

31

12

17

69

7

Ng

2004 [26]

China

359

359

115/244

Clinical or proven

a

Term

FCM

5500 $

93

46

22

198

8

Ng

2006 [27]

China

298

298

93/205

Clinical or proven

a

Term

FCM

6136 $

73

20

20

185

9

Zeitoun

2010 [30]

USA

98

98

49/49

Clinical or proven

c

Preterm + term

FCM

2.6*

45

14

4

35

10

Du

2014 [11]

China

158

158

88/70

Clinical

a

Preterm

FCM

1010 $

72

21

16

49

11

Elawady

2014 [12]

Egypt

50

50

25/25

Clinical

b

Preterm + term

FCM

46.0

24

0

1

24

12

Layseca-Espinosa

2002 [8]

Mexico

29

29

14/15

Clinical

c

Preterm  + term

FCM

#

3

0

11

15

13

Streimish(a)

2014 [29]

USA

684

1156

207/416

Clinical

a

Preterm

FCM

1.63

139

137

68

279

14

Streimish(b)

2014 [29]

USA

  

204/329

Clinical

b

Preterm

FCM

2.19

159

135

45

194

15

Choo

2012 [20]

Korea

23

23

11/12

Proven

c

Preterm + term

FCM

3.0*

10

2

1

10

16

Elawady

2014 [12]

Egypt

50

50

25/25

Proven

b

Preterm + term

FCM

45.8

24

0

1

25

17

Layseca-Espinosa

2002 [8]

Mexico

34

34

17/17

Proven

c

Preterm + term

FCM

#

5

1

12

16

18

Ng

2002 [9]

China

110

147

37/110

Proven

b

Preterm

FCM

4000 $

35

13

2

97

19

Soni

2013 [28]

India

60

60

24/36

Proven

c

Preterm + term

FCM

2.765*

22

12

2

24

20

Streimish(a)

2012 [19]

USA

649

997

3/577

Proven

a

Preterm

FCM

2.38

3

185

0

392

21

Streimish(b)

2012 [19]

USA

  

47/370

Proven

b

Preterm

FCM

3.62

35

85

12

285

  1. a, early-onset; b, late-onset; c, early & late-onset; *, CD64 index; FCM, flow cytometric technology; MFI: mean fluorescence intensity; Clinical infection defined as infection suspected on a clinical basis; proven infection defined as culture-proven infection with an identified micro-organism; #, Arithmetic mean + 3 SD of the percentage of CD64 + cells found in normal neonates; $: cAntibody-phycoerythrin molecules bound per cell