Table 5 Clinical measures of the evolution for the four subgroups at T0 and T1

13.79 ± 3.61

11.58 ± 3.82

<0.05

13.84 ± 3.83

11.23 ± 4.01

<0.0001

16.00 ± 3.64

14.11 ± 3.55

=0.120

12.50 ± 3.28

8.75 ± 4.11

<0.001

4.88 ± 1.85

3.75 ± 1.65

<0.05

4.90 ± 1.68

3.35 ± 1.58

<0.0001

5.44 ± 2.01

4.78 ± 1.48

=0.373

4.14 ± 1.53

2.68 ± 1.83

<0.001

8.92 ± 2.19

7.83 ± 2.58

=0.083

8.94 ± 2.41

7.87 ± 2.78

<0.01

10.56 ± 1.74

9.33 ± 2.29

=0.055

8.36 ± 2.18

6.07 ± 2.64

<0.01

2.67 ± 1.05

2.29 ± 1.27

=0.266

3.13 ± 1.09

2.48 ± 1.31

<0.01

3.44 ± 0.88

3.22 ± 1.30

=0.622

2.54 ± 1.14

2.11 ± 1.20

=0.089

3.92 ± 1.44

2.88 ± 1.62

<0.05

3.55 ± 1.67

3.52 ± 1.57

=0.903

4.44 ± 1.88

4.33 ± 2.06

=0.346

3.46 ± 1.40

2.68 ± 1.79

<0.01

5.58 ± 1.61

4.75 ± 1.36

<0.05

5.23 ± 1.63

4.68 ± 1.42

<0.05

5.56 ± 1.01

5.12 ± 1.05

=0.220

5.18 ± 1.19

3.93 ± 1.56

<0.01

0.61 ± 0.12

0.63 ± 0.11

=0.070

0.62 ± 0.13

0.65 ± 0.16

=0.190

0.50 ± 0.09

0.50 ± 0.07

=0.907

0.73 ± 0.12

0.76 ± 0.14

=0.060

0.67 ± 0.17

0.73 ± 0.16

<0.05

0.71 ± 0.20

0.76 ± 0.20

=0.087

0.55 ± 0.10

0.55 ± 0.14

=0.855

0.82 ± 0.16

0.90 ± 0.19

=0.055

0.38 ± 0.08

0.42 ± 0.14

=0.163

0.41 ± 0.12

0.45 ± 0.18

=0.179

0.36 ± 0.08

0.29 ± 0.08

<0.05

0.53 ± 0.23

0.59 ± 0.21

<0.05

0.46 ± 0.15

0.48 ± 0.12

=0.342

0.49 ± 0.14

0.53 ± 0.21

=0.156

0.42 ± 0.08

0.38 ± 0.10

=0.110

0.64 ± 0.20

0.73 ± 0.26

<0.05

0.70 ± 0.16

0.74 ± 0.14

=0.200

0.71 ± 0.14

0.71 ± 0.17

=0.733

0.59 ± 0.12

0.54 ± 0.07

=0.097

0.81 ± 0.12

0.81 ± 0.16

=0.995

0.76 ± 0.18

0.81 ± 0.19

=0.332

0.77 ± 0.15

0.76 ± 0.16

=0.629

0.60 ± 0.14

0.62 ± 0.13

=0.721

0.86 ± 0.13

0.82 ± 0.17

=0.112

0.66 ± 0.16

0.65 ± 0.10

=0.783

0.68 ± 0.14

0.70 ± 0.15

=0.448

0.55 ± 0.14

0.55 ± 0.09

=0.914

0.75 ± 0.11

0.73 ± 0.13

=0.586