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Table 1 The main laboratory parameters detected in this patient

From: Brain damage resembling acute necrotizing encephalopathy as a specific manifestation of haemophagocytic lymphohistiocytosis - induced by hypersensitivity

Laboratory parameters

Reference value

Results

Rheumatoid factor

0–20 IU/ml

<20

Anti-streptolysin “O”

0–200 IU/ml

<25

C-reactive protein

0–10 mg/L

19.5

Anti-cyclic-citrullinated peptide antibody

Negative

Autoantibodies

Antinuclear antibody

Positive

Antineutrophil cytoplasmic antiboby

Positive

Anti jo-1 antibody

Negative

Anti-centromere antibody

Negative

Anti-double-stranded dna antibody

Negative

Anti-histone antibody

Negative

Antismith antibody

Negative

Anti-rnp antibody

Negative

Anti-SS A antibody

Negative

Anti-SS B antibody

Negative

Anti-ribosomal antibody

Negative

Anti-Sc1-70 antibody

 

Negative

Anti-nucleosome antibody

Negative

Lymphocyte subsets

(Flow cytometry)

CD3+ T cell

68 % ± 10.7 %

66.1 %

CD4+ T cell

31.5 % ± 8.8 %

34.2 %

CD8+ T cell

25.7 % ± 6.5 %

19.66 %

CD19 B cell

15.6 % ± 5.8 %

19.1 %

NK cell

5.6 % - 31 %

9 %

CD4+/CD8+

1.5 ± 0.5

1.74

Ig isotypes

IgG

3.22 – 14.0 g/L

6.39

IgM

0.57 – 1.41 g/L

0.82

IgA

0.24 – 1.79 g/L

0.43

Complement C3

0.8 – 1.6 g/L

0.74

Complement C4

0.1 – 0.4 g/L

0.18

Total IgE

0 – 20 KIU/L

104.4

Ammonia

9 – 30 umol/L

19

Lactic acid

0.7 – 2.1 mmol/L

1.22

Coagulation test

Activated partial thromboplastin time

26.1 – 40.73 s

29.7a, over the upper limit of detectionb

Prothrombin time

9.3 –12.9 s

12.8a, over the upper limit of detectionb

International normalized ratio

0.72 – 1.15

1.09a, over the upper limit of detectionb

Thrombin time

13.2 – 20.1 s

20a, over the upper limit of detectionb

Fibrinogen

1.57 – 3.93 g/L

2.43a, 0.49b

Blood lipid levels

Total cholesterol

3.1 – 5.8 mmol/L

1.78a, 3.62b

Triglyceride

0.23 – 1.7 mmol/L

2.54a, 4.53b

High density lipoprotein

0.9 – 1.8 g/L

0.47a, 1.05b

Low density lipoprotein

2.07 – 4.1 g/L

1.1a, 1.8b

Serum ferritin

22 – 322 ng/ml

15.4a, 18699b

Values of eosinophils

0.02 – 0.5 × 109/L

0.26a, 4.01c, 0.01d

  1. Note: a - on admission, b - peak period of disease, c - the 2nd day after first IVIG, d - when severe pancytopenia