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Table 1 Classification of evidence for allergen-specific immunotherapy used in the manuscript

From: Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report

Level of evidence

Ia Evidence from meta-analysis of randomized controlled studies

Ib Evidence from at least one randomized controlled study

IIa Evidence from well-designed controlled trial without randomization

IIb Evidence from at least one other type of experimental study

III Evidence from non-experimental descriptive studies, including retrospective, case-control studies, cohort studies with controls

IV Evidence form opinions of respected authorities, based on clinical experience, or reports of expert committees

Grades of recommendations

A: Directly based on Level I evidence. A certain therapeutic intervention is strongly recommended.

B: Directly based on Level II evidence or extrapolated recommendations from Level I evidence. A certain therapeutic intervention should be carefully considered.

C: Directly based on Level III or IV evidence or extrapolated recommendations from Level I or II evidence. There is significant uncertainties about a certain therapeutic intervention.