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Table 3 Comparison of Genotype and Allele Frequency of IL-10 Polymorphisms between different clinical subtypes of JIA among studied patients

From: Association of IL-10 gene polymorphisms and susceptibility to Juvenile Idiopathic Arthritis in Egyptian children and adolescents: a case-control study

Genotype

 

sJIA

polyJIA

oligoJIA

OR (95% CI)

P

n = 23 (%)

n = 31 (%)

n = 46 (%)

IL-10 (-1082)

AA

6 (26)

13 (42) *

4 (9)

4.3 (1.5–12.7)

< 0.01

AG

16 (70)

15 (48)

38 (82)

GG

1 (4)

3 (10)

4 (9)

Alleles

 

A

28 (61)

41 (66)

46 (50)

 

> 0.05

G

18 (39)

21 (34)

46 (50)

−819/−592

TT/AA

5 (22)

8 (26)

10 (22)

 

> 0.05

CT/CA

14 (61)

17 (55)

34 (74)

CC/CC

4 (17)

6 (19)

2 (4)

Alleles

 

T/A

24 (55)

33 (54)

54 (17)

 

> 0.05

C/C

22 (44)

29 (45)

38 (17)

Serum IL10 (pg/ml)

 

5.7 ± 1.5

2.5 ± 1.3

9.6 ± 1.7

 

< 0.01a

  1. Abbreviations: IL-10, interleukin-10, sJIA systemic Juvenile idiopathic arthritis, poly JIA polyarticular Juvenile idiopathic arthritis, oligoJIA oligoarticular Juvenile idiopathic arthritis, OR odds ratio, CI 95% confidence interval
  2. Values in parentheses are percentages or data are presented as mean ± SD
  3. *P value < 0.05 indicates a significant difference. Chi-square test. a ANOVA-test