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Table 3 Comparison of Genotype and Allele Frequency of IL-10 Polymorphisms between different clinical subtypes of JIA among studied patients

From: Association of IL-10 gene polymorphisms and susceptibility to Juvenile Idiopathic Arthritis in Egyptian children and adolescents: a case-control study

Genotype   sJIA polyJIA oligoJIA OR (95% CI) P
n = 23 (%) n = 31 (%) n = 46 (%)
IL-10 (-1082) AA 6 (26) 13 (42) * 4 (9) 4.3 (1.5–12.7) < 0.01
AG 16 (70) 15 (48) 38 (82)
GG 1 (4) 3 (10) 4 (9)
Alleles
  A 28 (61) 41 (66) 46 (50)   > 0.05
G 18 (39) 21 (34) 46 (50)
−819/−592 TT/AA 5 (22) 8 (26) 10 (22)   > 0.05
CT/CA 14 (61) 17 (55) 34 (74)
CC/CC 4 (17) 6 (19) 2 (4)
Alleles
  T/A 24 (55) 33 (54) 54 (17)   > 0.05
C/C 22 (44) 29 (45) 38 (17)
Serum IL10 (pg/ml)   5.7 ± 1.5 2.5 ± 1.3 9.6 ± 1.7   < 0.01a
  1. Abbreviations: IL-10, interleukin-10, sJIA systemic Juvenile idiopathic arthritis, poly JIA polyarticular Juvenile idiopathic arthritis, oligoJIA oligoarticular Juvenile idiopathic arthritis, OR odds ratio, CI 95% confidence interval
  2. Values in parentheses are percentages or data are presented as mean ± SD
  3. *P value < 0.05 indicates a significant difference. Chi-square test. a ANOVA-test