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Table 2 Classification and comparison of the major systemically used glucocorticoids

From: Management of acute respiratory diseases in the pediatric population: the role of oral corticosteroids

Glucocorticoid Equivalent dose (mg) Anti-inflammatory potency* Salt retention* Suppressive HPA potency* Biological half-life (h)
Hydrocortisone 20 1 1 1 8–12 Short
Cortisone 25 0.8 0.8 1 8–12 Short
Prednisolone 5 4 0.8 1 12–36 Intermediate
Prednisone 5 4 0.8 1 12–36 Intermediate
Methylprednisolone 4 4–5 0.2–0.5 5 12–36 Intermediate
Triamcinolone 4 5–10 0 5 12–36 Intermediate
Dexamethasone 0.75 25 0 50 36–72 Long
Betamethasone 0.75 25 0 50 36–72 Long
  1. *Hydrocortisone as reference drug set equal to 1
  2. HPA hypothalamic-pituitary-adrenal axis