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Table 1 Cases of cervical spine GCTs in pediatric patients reported in the English literature

From: Denosumab treatment for progressive skull base giant cell tumor of bone in a 14 year old female – a case report and literature review

Article Patient, Age, Sex Location Therapy Tumor recurrence Last status Follow-up period (in years)
Dahlin DC, Cancer. 1977;39(3):1350–1356 [27] 3 patients, one 14 and two 17 years, all female 1.C2
2.C2
3. C4
All subtotal resection, one patient additional radiotherapy No ANED 1. 1,4 years
2. 4,8 years
3. 8,7 years
Di Lorenzo N, Neurosurgery. 1989;24(1): 37–42 [28] 1 patient, 17 years, Sex - N/A C2 Total resection No ANED 4 years
Hart et al., Spine (Phila Pa 1976). 1997;22(15):1773–1782 [29] 1 patient, 14 year, female C2 Intralesional curettage twice Multiple recurrences AWD 19 years
Honma et al., Spine (Phila Pa 1976). 1989;14(11):1204–1210 [30] 1 patient, 17 years, female C1-C2 Subtotal resection, radiotherapy (50Gy), chemotherapy Recurrence both after surgery and after radiotherapy DWD 2 years
Junming et al., Spine (Phila Pa 1976). 2008;33(3):280–288 [11] 1 patient, 17 years, female C7 En-bloc resection No ANED 7,7 years
Mirra et al., Clin Orthop Relat Res. (154):228–233 [31] 1 patient, 17 years, female C2 Cryosurgery and radiotherapy (46Gy) No ANED 2,5 years
Sanjay et al., Bone Joint J. 1993;75-B(1) [32] 4 patients, 14, 15 and two 17 years, all female 1. C2
2. C7
3. C2
4. C4
1. Anterior and posterior excision, additional surgery for recurrences
2. Anterior excision
3. Posterior excision, additional surgery for recurrence and radiotherapy (45Gy)
4. Posterior excision
1. Multiple recurrences
2. Multifocal lesions
3. One recurrence after first surgery
4. No
1. AWD
2. AWD
3. ANED
4. ANED
1. 4 years
2. 4 years
3. 20 years
4. 25 years
Shirzadi et al., J Neurosurg Pediatr. 2011;8(4):367–371 [33] 1 patient, 15 years, male C2 3 resections, radiotherapy (40Gy), chemotherapy, additional surgery No recurrence after last surgery ANED 10 years
Teng et al., J Neurosurg. 1951;8(5):482–493 [34] 1 patient, 15 years, female C6 Total resection and X-ray therapy N/A N/A N/A
Willard et al., Ann Surg. 1938;107(2):298–302 [35] 1 patient, 9 years, female C4 Subtotal resection No ANED 1 year
Our case 1 patient 14 year, female C1-C2, clivus, sphenoid Subtotal resection and radiotherapy Recurrence both after surgery and after radiotherapy AWD 1 year