Table 1 Cases of cervical spine GCTs in pediatric patients reported in the English literature

Dahlin DC, Cancer. 1977;39(3):1350–1356 [27]

3 patients, one 14 and two 17 years, all female

1.C2

2.C2

3. C4

All subtotal resection, one patient additional radiotherapy

No

ANED

1. 1,4 years

2. 4,8 years

3. 8,7 years

Di Lorenzo N, Neurosurgery. 1989;24(1): 37–42 [28]

1 patient, 17 years, Sex - N/A

C2

Total resection

No

ANED

4 years

Hart et al., Spine (Phila Pa 1976). 1997;22(15):1773–1782 [29]

1 patient, 14 year, female

C2

Intralesional curettage twice

Multiple recurrences

AWD

19 years

Honma et al., Spine (Phila Pa 1976). 1989;14(11):1204–1210 [30]

1 patient, 17 years, female

C1-C2

Subtotal resection, radiotherapy (50Gy), chemotherapy

Recurrence both after surgery and after radiotherapy

DWD

2 years

Junming et al., Spine (Phila Pa 1976). 2008;33(3):280–288 [11]

1 patient, 17 years, female

C7

En-bloc resection

No

ANED

7,7 years

Mirra et al., Clin Orthop Relat Res. (154):228–233 [31]

1 patient, 17 years, female

C2

Cryosurgery and radiotherapy (46Gy)

No

ANED

2,5 years

Sanjay et al., Bone Joint J. 1993;75-B(1) [32]

4 patients, 14, 15 and two 17 years, all female

1. C2

2. C7

3. C2

4. C4

1. Anterior and posterior excision, additional surgery for recurrences

2. Anterior excision

3. Posterior excision, additional surgery for recurrence and radiotherapy (45Gy)

4. Posterior excision

1. Multiple recurrences

2. Multifocal lesions

3. One recurrence after first surgery

4. No

1. AWD

2. AWD

3. ANED

4. ANED

1. 4 years

2. 4 years

3. 20 years

4. 25 years

Shirzadi et al., J Neurosurg Pediatr. 2011;8(4):367–371 [33]

1 patient, 15 years, male

C2

3 resections, radiotherapy (40Gy), chemotherapy, additional surgery

No recurrence after last surgery

ANED

10 years

Teng et al., J Neurosurg. 1951;8(5):482–493 [34]

1 patient, 15 years, female

C6

Total resection and X-ray therapy

N/A

N/A

N/A

Willard et al., Ann Surg. 1938;107(2):298–302 [35]

1 patient, 9 years, female

C4

Subtotal resection

No

ANED

1 year

Our case

1 patient 14 year, female

C1-C2, clivus, sphenoid

Subtotal resection and radiotherapy

Recurrence both after surgery and after radiotherapy

AWD

1 year