Skip to main content

Table 2 Cases of skull base GCTs in pediatric patients reported in the English literature

From: Denosumab treatment for progressive skull base giant cell tumor of bone in a 14 year old female – a case report and literature review

Article Patient, Age, Sex Location Therapy Tumor recurrence Last status Follow-up period (in years)
Bertoni et al., J Bone Joint Surg Am, 1985 Jul;67(6):890–900 1 patient, 8 years, female Temporal Gross total resection Recurrence AWD 2,5 years
Bibas-Bonet et al., Pediatr Neurol. 2003 May;28(5):392–5 1 patient, 8 years, female Temporal, sphenoid Radiotherapy N/A N/A 7 years
Carmody et al., J Comput Assist Tomogr. 1983 Apr;7(2):370–3 1 patient, 16 years, male Sphenoid Subtotal resection and radiotherapy No ANED 0,8 year
Do Amaral et al., J Craniofac Surg. 1994 Sep;5(4):254–6 1 patient, 14 years, female Sphenoid Gross total resection and radiotherapy No ANED 4 years
Elder et al., J Neurosurg. 2007 Jul;107(1 Suppl):69–74 2 patients, 2 years and 7 weeks, both female Both temporal Both gross total resection No ANED 1.1,1 years
2.0,9 years
Gupta et al., Br J Neurosurg, June 2008; 22(3): 447 –449 1 patient, 17 years, female Occipital Subtotal resection and radiotherapy No ANED 2 years
Inoue et al., World Neurosurg. 2016;91:674.e1–674.e6 1 patient, 16 years, male Sphenoid, clivus Subtotal resection and denosumab treatment after recurrence Recurrence after surgery, regress with denosumab AWD N/A
Kamoshima et al., Neurol Med Chir (Tokyo) 2011;51(11):798–800 1 patient, 2 years, female Frontal Gross tumor resection No ANED 1,5 years
Kattner et al., Skull Base Surg. 1998;8(2):93–7. 1 patient, 9 years, female Sphenoid Subtotal resection and radiotherapy No ANED 1 year
Kishima et al., Br J Neurosurg. 2001 Apr;15(2):171–4 1 patient, 12 years, female Sphenoid Debulking twice and radiotherapy on recurrence(50Gy) Recurrence after debulking, but stable after radiotherapy AWD 5 years
Sharma et al., Cases J. 2009; 2: 74 2 patients, 17 and 12 years, male and female 1. Sphenoid
2. Temporal
1. Subtotal resection and radiotherapy
2. Gross tumor resection
No ANED 1. 2 years
2. 1 year
Weber et al., Skull base surgery. 1997; 7(4):163–173 3 patients, 16, 11 and 10 years, male and two females All sphenoid All subtotal resection Yes (in all cases) AWD 1. 3,2 years
2. 1,5 years
3. 0,9 year
Wolfe et al., J Neurosurg. 1983;59(2):322–327 2 patients, both 16 years, female and male 1. Sphenoid, clivus, sella
2. Sella
Both subtotal resection and radiotherapy No ANED 1. 8 years
2. 2,5 years
Zhang et al., J Neurooncol. 2013;115(3):437–444 1 patient, 17 years, male Sphenoid Subtotal resection Yes AWD 1,6 years
Zorlu et al., J Neurooncol. 2006;76(2):149–152 1 patient, 14 years, female Sphenoid, clivus Debulking and radiotherapy (60Gy) on recurrence Recurrent both after surgery and after radiotherapy AWD 2 years