From: Pattern of drug use among preterm neonates: results from an Italian neonatal intensive care unit
GROUP A | GROUP B | |
---|---|---|
N = 68 | N = 91 | |
Gesational age, weeks | ||
Average | 26 | 30 |
Range | 22 – 32 | 27 – 36 |
Birth weight, g | ||
Average | 739 | 1309 |
Range | 380 – 1000 | 1023 – 1532 |
Discharge age, days | ||
Average | 57 | 23 |
Range | 2 – 218 | 1 – 175 |
Singleton birth, % | 77.9 | 71.4 |
Outcome, % | ||
Death | 17.7 | 3.3 |
Transfer | 4.4 | 5.5 |
Home | 77.9 | 91.2 |
Diseases, % | ||
Respiratory distress syndrome | 82.4 | 86.8 |
Anemia | 75.0 | 35.2 |
Hyperbilirubinemia | 70.6 | 93.4 |
Patent ductus arteriosus | 52.9 | 42.9 |
Sepsis | 38.2 | 11.0 |
Hyaline membrane disease | 27.9 | 5.5 |
Intrauterine growth restriction | 23.5 | 17.6 |
Central nervous system impairment | 22.1 | 8.8 |
Necrotizing enterocolitis | 13.2 | 5.5 |
Cardiac malformation | 11.8 | 15.4 |
Pharmacological treatments, % | 100 | 95.7 |
Number of drugs, % | ||
≤ 5 | 0 | 17.6 |
5–10 | 4.4 | 40.7 |
11–20 | 51.5 | 33.0 |
> 20 | 44.1 | 4.4 |
Combination of drugs, % | 100 | 93.4 |
Route of administration, % | ||
Drugs for systemic use | 100 | 96.7 |
Drugs for topical use | 82.4 | 57.1 |
Drugs for ophthalmic use | 44.1 | 14.3 |
Exposure to at least one drug with potential renal toxicitya, % | 100 | 93.4 |