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Table 2 Main advantages and disadvantages for the use of perampanel in childhood epilepsies

From: Current role of perampanel in pediatric epilepsy

Advantages

Disadvantages

Proved effectiveness in partial onset and primarily generalized seizures

Favourable cognitive profile

Single daily administration

Overall good risk/benefit ratio

Possible interaction with enzyme inducers AEDs

Possible psychiatric adverse events

Few data for children <12 years