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Table 3 Lung function measured at time zero (T0), after 4 (T4) and 16 weeks (T16) in the 12 children who inhaled normal saline

From: Effects of inhaled hypertonic (7%) saline on lung function test in preschool children with cystic fibrosis: results of a crossover, randomized clinical trial

 

T0

T4

T16

T0vsT4

T0vsT16

FVC (l)

1.31 ± 0.36

1.23 ± 0.28

1.29 ± 0.35

ns

ns

FVC % pred.

89.7 ± 8.3

85.4 ± 9.3

87.9 ± 9.1

p = 0.01

ns

FEV1 (1)

1.25 ± 0.25

1.07 ± 0.20

1.14 ± 0.24

p < 0.0001

p < 0.0001

FEV1% pred

90.7 ± 8.6

85.1 ± 7.9

87.8 ± 6.7

p < 0.0001

ns

FEF25-75 (l/s)

1.51 ± 0.39

1.30 ± 0.24

1.40 ± 0.30

p = 0.012

ns

FEF25-75% pred

78.7 ± 6.1

65.9 ± 9.7

72.1 ± 9.4

p = 0.001

p = 0.019

Rint exp. kPa (l/s)

1.23 ± 0.17

1.50 ± 0.33

1.29 ± 0.19

p = 0.02

ns

Rint insp. kPa (l/s)

1.19 ± 0.19

1.37 ± 0.49

1.26 ± 0.21

ns

ns

  1. Data were expressed as mean values ± SD