ESBL (+) n = 69 | ESBL (−) n = 42 | p | |
---|---|---|---|
Gendera | 0.99 | ||
Male | 37(63.8) | 21(36.2) | |
Female | 24(61.5) | 15(38.5) | |
Age (months)b | 4.9(1.7–26) | 16.4(3.1–69.1) | 0.04 |
Total length of hospitalization (days)b | 56(32–89) | 34(21–71) | 0.03 |
Length of stay in hospital before infection (days)b | 33(11.5–59.5) | 11.5(0–26) | 0.001 |
Duration of treatment for infection (days)b | 16(11–21.5) | 17(12–23) | 0.66 |
Underlying medical condition/diseasea | NA | ||
Hematologic malignancy | 7(11.4) | 8(22.2) | |
Oncologic malignancy | 6(9.8) | 10(27.2) | |
Congenital heart anomalies | 8(13.1) | 4(11.1) | |
Primary immunodeficiencies | 2(3.2) | 1(2.7) | |
Neurologic/Metabolic disease | 10(16.3) | 4(11.1) | |
Gastrointestinal disease | 9(14.7) | 6(16.6) | |
Prematurity | 6(9.8) | 1(2.7) | |
Others | 13(21.3) | 2(5.5) | |
Mechanical ventilationa | 31(81.6) | 7(18.4) | 0.005 |
Presence of central venous cathetera | 34(60.7) | 22(39.3) | 0.90 |
Prior surgerya | 33(66) | 17(34) | 0.57 |
Polymicrobial bacteremiaa | 6(42.9) | 8(57.1) | 0.19 |
Prior chemotherapy associated neutropeniaa | 15(46.9) | 17(53.1) | 0.058 |
Prior K. pneumoniae colonizationa | 7 | 5 | NA |
Prior antibiotic usea | |||
Broad spectrum cephalosporins | 21(75) | 7(25) | 0.16 |
Fluoroquinolones | 15(75) | 5(25) | 0.29 |
Carbapenems | 25(61) | 16(39) | 1.0 |
Aminoglycosides | 47(77) | 14(23) | 0.001 |
Glycopeptides | 35(71.4) | 14(28.6) | 0.11 |
Use of more than one of the antibiotics studieda | 52(75.4) | 17(24.6) | 0.001 |
Outcomea | |||
Crude Mortality | 20 (29) | 7 (16.7) | 0.21 |
30 day mortality | 17(24.6) | 5 (11.9) | 0.16 |
60 day mortality | 19 (27.5) | 7(16.7) | 0.28 |
Response at day 6 | 42(58.3) | 30(41.7) | 0.44 |
Relapse | 5(4.5) | 4(3.6) | 0.67 |