MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies

Table 1 The main characteristics of all included studies for MTHFR A1298C polymorphism

Study	Year	Country	CASE			CONTROL			HWE
			AA	AC	CC	AA	AC	CC
Storti	2003	Italy (Europe)	45	47	11	101	86	13	0.347	VSD, TOF, DORV, PA, TGA, AC
Galdieri	2007	Brasil (America)	35	21	1	19	16	3	0.885	CHD
van Driel	2008	Netherland (Europe)	112	90	27	97	129	25	0.057	TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS
Locke	2010	USA (America)	42	39	6	30	49	9	0.090	ASD, VSD, AVSD
Obermann-Borst	2010	Netherland (Europe)	69	57	13	75	90	18	0.227	TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS
Xu	2010	China (Asia)	316	168	18	326	185	16	0.091	Cyanotic Cardiac Disease, ASD, VSD, PDA, Left-sided Obstruction Defects
Božovic	2011	Europe	30	22	2	25	30	3	0.113	ASD, VSD, AVSD, PFO, TOF, PDA, Persistent truncus arteriosus
Christensen	2013	Canada (America)	78	67	12	38	26	5	0.849	VSD, TOF, AS, TGA, AVSD, DORV, PS, CoA, Truncus Arteriosus
Sahiner	2013	Turkey (Europe)	45	68	24	31	54	8	0.022	Obstruction in LV Output, Left-to-right Shunt, Conotruncal Anomalies,Complex Anomalies
Wang	2013	China (Asia)	115	40	5	133	47	8	0.155	CHD
Zidan	2013	Egypt (Africa)	16	27	37	30	26	24	0.002	ASD, VSD, PDA, Combined lesion, PS, TOF, HLHS
Chao	2014	China (Asia)	13	2	2	15	19	0	0.024	PDA
Huang	2014	China (Asia)	111	56	3	146	54	6	0.712	TOF
Sayin Kocakap	2014	Turkey (Europe)	20	36	13	51	37	11	0.288	PS, ASD, VSD, AVSD, TAPVR, TA, PA
Li	2015	China Asia)	114	36	0	131	19	0	0.408	VSD, ASD, PDA, TOF, CoA, AS, PS, TGA, DORV, Persistent truncus arteriosus
Koshy	2015	India (Asia)	27	32	37	58	20	22	0	TOF, DORV, PA-VS, TA, IAA

AC Aortic Coarctation, AS Aortic Stenosis, ASD Atrial septal defect, AVSD Atrioventricular septal defect, CHD congenital heart disease, CoA Coarctation of the aorta, DORV Double outlet right ventricle, HLHS Hypoplastic left heart syndrome, IAA Interrupted aortic arch, PA Pulmonary atresia, PDA Patent ductus arteriosus, PS Pulmonary stenosis, TA Tricuspid atresia, TAPVR Total anomalous pulmonary venous return, TGA Transposition of great arteries, TOF Tetralogy of Fallot, VSD Ventricular septal defect

ISSN: 1824-7288