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Table 1 The main characteristics of all included studies for MTHFR A1298C polymorphism

From: MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies

Study Year Country CASE CONTROL HWE  
    AA AC CC AA AC CC   
Storti 2003 Italy (Europe) 45 47 11 101 86 13 0.347 VSD, TOF, DORV, PA, TGA, AC
Galdieri 2007 Brasil (America) 35 21 1 19 16 3 0.885 CHD
van Driel 2008 Netherland (Europe) 112 90 27 97 129 25 0.057 TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS
Locke 2010 USA (America) 42 39 6 30 49 9 0.090 ASD, VSD, AVSD
Obermann-Borst 2010 Netherland (Europe) 69 57 13 75 90 18 0.227 TOF, TGA, ASD, VSD, CoA, AS, PS, HLHS
Xu 2010 China (Asia) 316 168 18 326 185 16 0.091 Cyanotic Cardiac Disease, ASD, VSD, PDA, Left-sided Obstruction Defects
Božovic 2011 Europe 30 22 2 25 30 3 0.113 ASD, VSD, AVSD, PFO, TOF, PDA, Persistent truncus arteriosus
Christensen 2013 Canada (America) 78 67 12 38 26 5 0.849 VSD, TOF, AS, TGA, AVSD, DORV, PS, CoA, Truncus Arteriosus
Sahiner 2013 Turkey (Europe) 45 68 24 31 54 8 0.022 Obstruction in LV Output, Left-to-right Shunt, Conotruncal Anomalies,Complex Anomalies
Wang 2013 China (Asia) 115 40 5 133 47 8 0.155 CHD
Zidan 2013 Egypt (Africa) 16 27 37 30 26 24 0.002 ASD, VSD, PDA, Combined lesion, PS, TOF, HLHS
Chao 2014 China (Asia) 13 2 2 15 19 0 0.024 PDA
Huang 2014 China (Asia) 111 56 3 146 54 6 0.712 TOF
Sayin Kocakap 2014 Turkey (Europe) 20 36 13 51 37 11 0.288 PS, ASD, VSD, AVSD, TAPVR, TA, PA
Li 2015 China Asia) 114 36 0 131 19 0 0.408 VSD, ASD, PDA, TOF, CoA, AS, PS, TGA, DORV, Persistent truncus arteriosus
Koshy 2015 India (Asia) 27 32 37 58 20 22 0 TOF, DORV, PA-VS, TA, IAA
  1. AC Aortic Coarctation, AS Aortic Stenosis, ASD Atrial septal defect, AVSD Atrioventricular septal defect, CHD congenital heart disease, CoA Coarctation of the aorta, DORV Double outlet right ventricle, HLHS Hypoplastic left heart syndrome, IAA Interrupted aortic arch, PA Pulmonary atresia, PDA Patent ductus arteriosus, PS Pulmonary stenosis, TA Tricuspid atresia, TAPVR Total anomalous pulmonary venous return, TGA Transposition of great arteries, TOF Tetralogy of Fallot, VSD Ventricular septal defect