Skip to main content

Table 2 Subgroup analysis of the association between MTHFR A1298C polymorphism and CHD

From: MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies

Subgroup analysis

Genetic model

C vs. A

CC vs. AA

CC vs. AC

AC vs. AA

Dominant model

Recessive model

No.

OR

95% CI

No.

OR

95% CI

No.

OR

95% CI

No.

OR

95% CI

No.

OR

95% CI

No.

OR

95% CI

Summary

16

1.13

0.92–1.37

15

1.33

0.92–1.92

15

1.25

0.98–1.60

16

1.05

0.81–1.36

16

1.10

0.84–1.43

15

1.38

1.10–1.73

HWE

 Consistent

12

1.02

0.85–1.21

11

1.02

0.73–1.42

11

1.14

0.85–1.52

12

1.00

0.78–1.28

12

1.00

0.79–1.28

11

1.10

0.83–1.44

 Inconsistent

4

1.55

0.94–2.57

4

2.97

1.89–4.66

4

1.59

1.01–2.50

4

1.11

0.40–3.06

4

1.37

0.56–3.36

4

2.21

1.49–3.27

Down’s syndrome

 Without

14

1.20

0.98–1.47

13

1.47

1.01–2.14

13

1.29

1.00–1.66

14

1.14

0.86–1.50

14

1.19

0.90–1.57

13

1.44

1.14–1.82

 With

2

0.69

0.48–0.98

2

0.50

0.19–1.31

2

0.86

0.33–2.23

2

0.59

0.36–0.95

2

0.57

0.36–0.92

2

0.66

0.26–1.68

Region

 Europe

6

1.06

0.81–1.40

6

1.36

0.85–2.17

6

1.48

1.05–2.09

6

0.91

0.62–1.35

6

0.98

0.66–1.46

6

1.40

1.01–1.94

 Asia

6

1.27

0.87–1.85

5

1.44

0.67–3.13

5

1.06

0.68–1.66

6

1.27

0.79–2.04

6

1.28

0.80–2.05

5

1.42

0.95–2.14

 America

3

0.81

0.55–1.21

3

0.62

0.26–1.50

3

0.78

0.37–1.65

3

0.82

0.49–1.36

3

0.78

0.45–1.34

3

0.72

0.35–1.49

Sample size

 Large (>100)

9

1.05

0.90–1.22

8

1.10

0.82–1.49

8

1.30

0.96–1.77

9

1.01

0.80–1.28

9

1.03

0.83–1.28

8

1.21

0.91–1.62

 Small (<100)

7

1.13

0.69–1.87

7

1.60

0.74–3.45

7

1.17

0.78–1.76

7

1.02

0.51–2.05

7

1.09

0.54–2.21

7

1.68

1.17–2.41

Back to article page

Italian Journal of Pediatrics

ISSN: 1824-7288

Contact us