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Table 3 Sensitivity analysis of the association between MTHFR A1298C and CHD by omitting a single study each time

From: MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies

Study omitted Genetic model
C vs. A CC vs. AA CC vs. AC AC vs. AA Dominant model Recessive model
OR 95% CI OR 95% CI OR 95% CI OR 95% CI OR 95% CI OR 95% CI
Storti 1.11 0.90–1.38 1.28 0.86–1.91 1.23 0.96–1.59 1.04 0.79–1.37 1.08 0.82–1.43 1.35 1.07–1.71
Galdieri 1.16 0.95–1.41 1.39 0.97–2.00 1.28 1.00–1.63 1.07 0.82–1.41 1.13 0.86–1.48 1.40 1.12–1.76
van Driel 1.16 0.94–1.42 1.37 0.92–2.05 1.21 0.92–1.57 1.11 0.85–1.44 1.15 0.87–1.50 1.41 1.10–1.80
Locke 1.17 0.95–1.43 1.43 0.99–2.06 1.28 1.00–1.64 1.10 0.84–1.43 1.15 0.88–1.50 1.43 1.13–1.80
Obermann-Borst 1.16 0.94–1.42 1.39 0.94–2.06 1.27 0.98–1.64 1.10 0.83–1.43 1.14 0.86–1.50 1.43 1.13–1.81
Xu 1.14 0.91–1.42 1.33 0.88–2.01 1.26 0.97–1.63 1.06 0.79–1.43 1.11 0.82–1.50 1.40 1.10–1.78
Božovic 1.15 0.94–1.41 1.36 0.93–1.99 1.26 0.99–1.61 1.09 0.83–1.42 1.13 0.87–1.49 1.39 1.11–1.75
Christensen 1.12 0.91–1.39 1.33 0.90–1.98 1.27 0.99–1.63 1.04 0.79–1.37 1.09 0.82–1.44 1.39 1.11–1.76
Sahiner 1.12 0.91–1.38 1.27 0.86–1.89 1.19 0.92–1.53 1.07 0.81–1.41 1.10 0.83–1.46 1.33 1.05–1.68
Wang 1.14 0.93–1.41 1.38 0.94–2.03 1.28 1.00–1.65 1.06 0.80–1.40 1.11 0.84–1.47 1.41 1.12–1.78
Zidan 1.08 0.89–1.32 1.23 0.84–1.81 1.23 0.95–1.59 1.02 0.78–1.33 1.05 0.81–1.37 1.31 1.03–1.66
Chao 1.15 0.94–1.40 1.30 0.89–1.89 1.23 0.97–1.57 1.10 0.86–1.41 1.14 0.88–1.48 1.36 1.09–1.71
Huang 1.12 0.91–1.39 1.37 0.94–2.01 1.29 1.01–1.65 1.03 0.78–1.36 1.08 0.82–1.43 1.41 1.12–1.77
Sayin Kocakap 1.09 0.89–1.33 1.24 0.85–1.82 1.26 0.98–1.62 1.00 0.78–1.29 1.04 0.80–1.35 1.35 1.07–1.70
Li 1.09 0.89–1.33 1.33 0.92–1.92 1.25 0.98–1.60 1.00 0.78–1.30 1.05 0.81–1.37 1.38 1.10–1.73
Koshy 1.06 0.89–1.26 1.21 0.86–1.71 1.28 0.99–1.65 0.99 0.78–1.25 1.02 0.80–1.29 1.28 1.01–1.63
Combined 1.13 0.92–1.37 1.33 0.92–1.92 1.25 0.98–1.60 1.05 0.81–1.36 1.10 0.84–1.43 1.38 1.10–1.73