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Table 4 Heterogeneity analysis of the association between MTHFR A1298C polymorphism and CHD

From: MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies

Subgroup analysis Genetic model
C vs. A CC vs. AA CC vs. AC AC vs. AA Dominant model Recessive model
Heterogeneity Meta-regression Heterogeneity Meta-regression Heterogeneity Meta-regression Heterogeneity Meta-regression Heterogeneity Meta-regression Heterogeneity Meta-regression
I2 (%) P P I2 (%) P P I2 (%) P P I2 (%) P P I2 (%) P P I2 (%) P P
Summary 73.0 0.000   51.1 0.012   0.0 0.569   70.6 0.000   74.5 0.000   14.7 0.289  
HWE    0.076    0.002    0.248    0.558    0.308    0.014
 Consistent 58.4 0.006   20.3 0.251   0.0 0.859   63.7 0.001   65.3 0.001   0.0 0.709  
 Inconsistent 75.5 0.007   0.0 0.784   46.0 0.135   83.1 0.000   83.6 0.000   0.0 0.769  
Down’s syndrome    0.111    0.106    0.433    0.186    0.143    0.149
 Without 73.2 0.000   49.8 0.021   0.0 0.461   71.7 0.000   75.1 0.000   13.6 0.308  
 With 0.0 0.908   0.0 0.890   0.0 0.941   0.0 0.886   0.0 0.856   0.0 0.940  
Region    0.218    0.466    0.492    0.224    0.230    0.534
 Europe 68.0 0.008   38.9 0.147   0.0 0.846   68.5 0.007   72.0 0.003   0.0 0.594  
 Asia 79.2 0.000   60.3 0.039   36.2 0.180   78.9 0.000   80.9 0.000   40.5 0.151  
 America 44.7 0.164   20.4 0.285   0.0 0.612   40.5 0.186   50.2 0.134   0.0 0.441  
Sample size    0.723    0.180    0.679    0.874    0.818    0.214
 Large (>100) 38.7 0.110   0.0 0.619   0.0 0.603   57.3 0.016   53.1 0.029   0.0 0.664  
 Small (<100) 83.8 0.000   64.0 0.011   12.0 0.338   80.7 0.000   84.5 0.000   37.1 0.145