Table 4 Heterogeneity analysis of the association between MTHFR A1298C polymorphism and CHD
Subgroup analysis | Genetic model | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C vs. A | CC vs. AA | CC vs. AC | AC vs. AA | Dominant model | Recessive model | |||||||||||||
Heterogeneity | Meta-regression | Heterogeneity | Meta-regression | Heterogeneity | Meta-regression | Heterogeneity | Meta-regression | Heterogeneity | Meta-regression | Heterogeneity | Meta-regression | |||||||
I2 (%) | P | P | I2 (%) | P | P | I2 (%) | P | P | I2 (%) | P | P | I2 (%) | P | P | I2 (%) | P | P | |
Summary | 73.0 | 0.000 | 51.1 | 0.012 | 0.0 | 0.569 | 70.6 | 0.000 | 74.5 | 0.000 | 14.7 | 0.289 | ||||||
HWE | 0.076 | 0.002 | 0.248 | 0.558 | 0.308 | 0.014 | ||||||||||||
Consistent | 58.4 | 0.006 | 20.3 | 0.251 | 0.0 | 0.859 | 63.7 | 0.001 | 65.3 | 0.001 | 0.0 | 0.709 | ||||||
Inconsistent | 75.5 | 0.007 | 0.0 | 0.784 | 46.0 | 0.135 | 83.1 | 0.000 | 83.6 | 0.000 | 0.0 | 0.769 | ||||||
Down’s syndrome | 0.111 | 0.106 | 0.433 | 0.186 | 0.143 | 0.149 | ||||||||||||
Without | 73.2 | 0.000 | 49.8 | 0.021 | 0.0 | 0.461 | 71.7 | 0.000 | 75.1 | 0.000 | 13.6 | 0.308 | ||||||
With | 0.0 | 0.908 | 0.0 | 0.890 | 0.0 | 0.941 | 0.0 | 0.886 | 0.0 | 0.856 | 0.0 | 0.940 | ||||||
Region | 0.218 | 0.466 | 0.492 | 0.224 | 0.230 | 0.534 | ||||||||||||
Europe | 68.0 | 0.008 | 38.9 | 0.147 | 0.0 | 0.846 | 68.5 | 0.007 | 72.0 | 0.003 | 0.0 | 0.594 | ||||||
Asia | 79.2 | 0.000 | 60.3 | 0.039 | 36.2 | 0.180 | 78.9 | 0.000 | 80.9 | 0.000 | 40.5 | 0.151 | ||||||
America | 44.7 | 0.164 | 20.4 | 0.285 | 0.0 | 0.612 | 40.5 | 0.186 | 50.2 | 0.134 | 0.0 | 0.441 | ||||||
Sample size | 0.723 | 0.180 | 0.679 | 0.874 | 0.818 | 0.214 | ||||||||||||
Large (>100) | 38.7 | 0.110 | 0.0 | 0.619 | 0.0 | 0.603 | 57.3 | 0.016 | 53.1 | 0.029 | 0.0 | 0.664 | ||||||
Small (<100) | 83.8 | 0.000 | 64.0 | 0.011 | 12.0 | 0.338 | 80.7 | 0.000 | 84.5 | 0.000 | 37.1 | 0.145 | ||||||