Skip to main content

Table 1 Prediction score models of IVIG resistance in KD patients

From: A comparison of efficacy of six prediction models for intravenous immunoglobulin resistance in Kawasaki disease

Prediction models Nation Year Enrolled patients, n Patients with IVIG resistance, n Sensitivity, % Specificity, % Risk factors Points Predicted risk (score)
Kobayashi Japan 2006 528 148 86 68 Age ≤ 12 mo 1 Low risk (0–2)
High risk (≥ 3)
Illness days ≤4 d 2
CRP ≥ 10 mg/dL 1
AST ≥ 100 IU/L 2
PLT ≤ 300 ×  109/L 1
Na ≤ 133 mmol/L 2
N% ≥ 80% 2
Egami Japan 2006 320 41 78 76 Age ≤ 6 mo 1 Low risk (0–2)
High risk (≥ 3)
Illness days ≤4 d 1
CRP ≥ 8 mg/dl 1
ALT ≥80 IU/L 2
PLT < 300 × 109/L 1
Kawamura Japan 2016 405 85 71 69 NLR ≥ 3.83
PLR ≥ 150
-
-
Sano Japan 2007 112 22 77 86 CRP ≥ 7.0 mg 1 Low risk (0–1)
High risk (≥ 2)
TB ≥ 0.9 mg/dl 1
AST ≥ 200 IU/L 1
Formosa Taiwan 2015 248 29 86.2 81.3 lymphadenopathy 1 Low risk (0–2)
N% ≥ 60% 2 High risk (≥ 3)
ALB < 35 g/L 1  
Ours China 2016 910 46 71.4 76.0 Age <  6 months 2 Low risk (0–2)
High risk (≥ 3)
Rash 1
Edema of extremities 1
N% ≥80% 1
ALB < 35 g/L 2
  1. CRP c-reactive protein, PLT platelet count, Na serum sodium, N% percentage of neutrophils, ALB serum albumin, ALT alanine aminotransferase, AST aspartate aminotransferase, TB total bilirubin, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio