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Table 2 Demographic, clinical and laboratory characteristics between intravenous immunoglobulin (IVIG) resistant and IVIG responsive KD patients

From: A comparison of efficacy of six prediction models for intravenous immunoglobulin resistance in Kawasaki disease

Variables Total (n = 504) IVIG resistant patients (n = 479) IVIG responsive patients (n = 25) P value
Male, n (%) 318 (63.1) 303 (60.1) 15 (3.0) 0.726
Age in months, median (quartile) 20 (11, 36) 20 (11, 35) 15 (5.5, 42.5) 0.456
<  1 yr., n (%) 153 (30.4) 142 (28.2) 11 (2.2) 0.128
< 6 months, n (%) 58 (11.5) 51 (10.1) 7 (1.4) 0.008
Oral mucosal changes, n (%) 457 (90.7) 435 (86.3) 22 (4.4) 0.720*
Strawberry tongue, n (%) 384 (76.2) 367 (72.8) 16 (3.2) 0.150
Rash, n (%) 394 (78.2) 370 (73.4) 24 (4.8) 0.027
Edema of extremities, n (%) 224 (44.4) 204 (40.5) 20 (4.0) < 0.001
Desquamation of the fingertips, n (%) 268 (53.2) 252 (50.0) 16 (3.2) 0.266
Cervical lymphadenopathy, n (%) 398 (79.0) 380 (79.4) 18 (3.6) 0.381
Days of illness at initial treatment, mean ± SD (median), days 6.8 ± 2.0 (6.0) 6.8 ± 2.0 (6.0) 6.2 ± 2.0 (6.0) 0.156
CRP, median (quartile), mg/dl 69.1 (37.6, 112.7) 65.6 (36.3, 111.4) 94.4 (84.2, 134.9) 0.001
ALT, median (quartile), IU/L 22.7 (13.4, 55.7) 22.2 (13.2, 54.1) 29.5 (17.8, 104.5) 0.051
AST, median (quartile), IU/L 31.0 (24.3, 43.8) 31.0 (24.1, 43.0) 42.6 (28.5, 53.6) 0.034
Na, mean ± SD (median), mmol/L 135 (133, 137) 135 (133, 137) 133 (131, 137) 0.247
ALB, mean ± SD (median), g/L 38.6 (35.8, 40.7) 38.8 (35.8, 40.8) 36.3 (32.8, 38.8) 0.005
PLT, mean ± SD (median), × 109/L 357 (284, 453) 357 (287, 454) 365 (224, 400) 0.169
N%, mean ± SD (median) 65.3 (53.3, 75.2) 64.9 (53.4, 74.6) 76.8 (55.9, 89.1) 0.026
NLR, mean ± SD (median) 2.4 (1.4, 4.1) 2.4 (1.4, 4.1) 3.5 (1.1, 11.7) 0.198
PLR, mean ± SD (median) 100.8 (69.2, 145.1) 100.4 (68.9, 144.1) 118.7 (71.0, 218.8) 0.158
TB, mean ± SD (median), mmol/L 5.1 (3.5, 7.7) 5.0 (3.5, 7.5) 7.9 (5.0, 11.2) 0.002
  1. SD standard deviation, CRP c-reactive protein, PLT platelet count, Na serum sodium, N% percentage of neutrophils, ALB serum albumin, ALT alanine aminotransferase, AST aspartate aminotransferase, TB total bilirubin, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio
  2. *Fisher’s exact test was used