Children with fasting plasma glucose ≥100 mg/dl or HbA1c ≥5.7–6.4% (39–46 mmol/mol) Adolescents (> 10 years of age) or at onset of puberty with overweight (BMI > 85th percentile) and at least one of the following risk factors: - Family history of T2DM in first- or second-degree relatives; - Race/ethnicity (African American, Latino, Native American, Asian American, or Pacific Islander); - Signs or conditions associated with insulin resistance (hypertension, dyslipidaemia, polycystic ovary syndrome, acanthosis nigricans, or small for gestational age at birth) - Maternal history of diabetes or gestational diabetes during the child’s gestation - Non alcholic liver disease - TG/HDL-Cholesterol ≥2.2 - Fasting plasma glucose ≥86 mg/dl - TG > 100 mg/dl and fasting plasma glucose > 80 mg/dl |