Table 2 Previous studies that analyzed the relationship between MTHFR polymorphisms migraine compared to ours

Orsini et al. (our study).

77/220 (35%)

–

9.83 (3–17)

Hamza Alsayouf et al. (J.child neurology, 2011)

11/41 (26.8%)

–

15 (1 day-20 yrs)

Bottini et al., (Cephalalgia. 2006)

12/45 (26.7%)

9/66 (13.6%) (age 15–41)

11.6 (5–17)

Di Rosa G et al., Headache. 2007

11/16 (68%)

–

12 (8–18)

Ferrara M [12], Hematology. 2012

15/42 (35.7%)

11.9% (age 9 to 15)

8.9 (7.5–14.5).

Herak DC, Pediatrics. 2009

6/35 (17.1%)

10/112 (8.9%) (age < 18 years)

12 (6–17)