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Table 2 Previous studies that analyzed the relationship between MTHFR polymorphisms migraine compared to ours

From: Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service

  C677T MTHFR Polymorphism TT genotype in children with migraine C677T MTHFR Polymorphism TT genotype in general pediatric population Age in years
Orsini et al. (our study). 77/220 (35%) 9.83 (3–17)
Hamza Alsayouf et al. (J.child neurology, 2011) 11/41 (26.8%) 15 (1 day-20 yrs)
Bottini et al., (Cephalalgia. 2006) 12/45 (26.7%) 9/66 (13.6%) (age 15–41) 11.6 (5–17)
Di Rosa G et al., Headache. 2007 11/16 (68%) 12 (8–18)
Ferrara M [12], Hematology. 2012 15/42 (35.7%) 11.9% (age 9 to 15) 8.9 (7.5–14.5).
Herak DC, Pediatrics. 2009 6/35 (17.1%) 10/112 (8.9%) (age < 18 years) 12 (6–17)